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Table 5 The distribution of the somatic variants observed among the paired MPMs from the same patients included into the study

From: Germline and somatic mutations in patients with multiple primary melanomas: a next generation sequencing study

Patient

Sample

Sequence variants

1

M1

CDKN2AG23S, PIK3CAI391M, TP53S99F

M2

CDKN2A G23S , TP53 E286K

M3

CDKN2AG23S, TP53P72R

M4

CDKN2AG23S, CDKN2AA148T, PIK3CAT1031I, TP53P8S

2

M1

BRAF V600E , TP53 R248W

M2

JAK3V722I

M3

BRAFV600E, ERBB4Q264P, FBXW7T482A, KDRT875A, META179T, SMOL410Q

M4

BRAFV600E, TP53P72A

M5

BRAF V600E

M6

BRAF V600E

M7

BRAF V600E

M8

BRAFV600E, TP53S96P

3

M1

BRAFV600E, KITM541L, TP53P72R

M2

APCA1351T, BRAFV600E, STK11splicing, TP53H179Y

M3

PIK3CAI391M, TP53P72R, TP53E286K

M4

BRAFV600E, PIK3CAI391M

M5

BRAFV600E, KDRG1333R, PIK3CAI391M, TP53P72R

4

M1

NRASG12D, PIK3CAD1045Y

M2

PIK3CAI391M, PIK3CAK468fs, TP53P72R

M3

NRASG12D, PIK3CAG903R, TP53P278S

M4

KDRQ472H, PIK3CAG1049S

M5

KDRQ472H, PIK3CAI391M, TP53P72R

5

M1

BRAFV600E, KITM541L, TP53P72R, TP53R196*

M2

BRAFV600E, BRAFK601I

M3

BRAFV600E, PIK3CAN107H, TP53P72R

M4

BRAFV600E, TP53P72R

M5

BRAFV600E, KDRQ472H, KITM541L

M6

BRAFV600E, KDRQ472H, KITM541L

  1. In bold, variants classified as pathogenic/likely pathogenic mutations