Table 4 Main phenotypic and familial characteristic of patients with at least four MPMs
Case | Phototype | Hair colour | Eyes colour | Total nevi | Family member(s) with CM (No.) | Total CMs in family | Total CMs in MPM proband | Timing | Site(s) of 1st CM(s) | AJCC Stage | Germinal CDKN2A mutation | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1st | 2nd | 3rd | 4th | 5th | 6th | 7th | 8th | |||||||||||
1 | II | Light brown | Green | 21–100 | brother (1), sister (2) | 7 | 4 | M | Trunk | IA | IIA | IA | IIB | – | – | – | – | G23S |
2 | II | Light brown | Green | < 20 |  | 8 | 8 | S | Lower limb | IB | IA* | IA* | IA | IA | IA | 0 | IB | wt |
3 | III | Dark brown | Dark brown | < 20 |  | 5 | 5 | S | Upper limb | IB | IB | IB* | IA* | IA | – | – | – | wt |
4 | I | Red | Light brown | < 20 | daughter (1) | 6 | 5 | S | Trunk Upper limb | IB* | IIA* | IA | IB | IA | – | – | – | wt |
5 | III | Dark brown | Dark brown | < 20 |  | 6 | 6 | M | Lower limb Lower limb | IA* | IA* | IA | IB | IB | IA | – | – | wt |