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Table 1 Main clinical and epidemiological characteristic of patients with multiple primary melanomas

From: Germline and somatic mutations in patients with multiple primary melanomas: a next generation sequencing study

Characteristics

No.

%

p value

Total patients

102

  

Gender

 Male

47

46.1

0.546

 Female

55

53.9

 

Median age at 1st CMM diagnosis (IQR range)

 Male

55 (40–66)

0.524

 Female

52 (42–60)

  

No. of melanomas/patients

 2

86

84.3

< 0.001

 3

11

10.8

 

  > 3

5

4.9

 

Presentation of MPMs

 Synchronous

21

20.6

< 0.001

 Metachronous

81

79.4

 

Incidence of 2nd melanomas

  < 1 year

37

36.3

0.098

  > 1 year < 3 years

41

40.2

 

  > 3 years

24

23.5

 

No. of total naevi

  < 20

28

27.5

< 0.001

 21–100

56

54.9

 

  > 100

18

17.6

 

Fitzpatrick phototype

 I

10

9.8

 

 II

41

40.2

< 0.001

 III

45

44.1

 

 IV

6

5.9

 

Sunburns in childhood

 Yes

90

88.2

< 0.001

 No

12

11.8

 

Family history of melanoma

 Yes

16

15.7

< 0.001

 No

86

84.3

 
  1. Significance (p) has been evaluated for MPM occurrence according to each patients’ feature. CMM cutaneous malignant melanoma, MPM multiple primary melanoma, IQR interquartile range. Statistical significance at 0.05