Fig. 3

Gene expression profiles changes associated with miR-182 silencing in MICOL-14^h-tert and MICOL-14^tum cells. A. Principal Component Analysis (PCA) of samples according to transcript expression profiles measured by Primeview array analysis indicates differences among control samples of different cell lines and more importantly, for each cell line, a clear separation of anti-miR-182 treated and control samples pointed toward the readout of miR-182 silencing. B. Number of significantly up- or down-regulated transcripts differentially expressed is compared between anti-miR-182-treated and control samples in MICOL-14^h-tert and MICOL-14^tum cells