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Fig. 2 | BMC Cancer

Fig. 2

From: Urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells: a case report

Fig. 2

Histopathological findings of the urinary bladder leiomyosarcoma with osteoclast-like multinucleated giant cells. a, b Hematoxylin and eosin-stained (HE) shows a tumour composed of spindle cells with blunt-ended, cigar-shaped nuclei and copious eosinophilic cytoplasm without marked cellular atypia. The most striking feature is the presence of numerous multinucleated, osteoclast-like giant cells (OGCs), scattered throughout the neoplasm and, even when numerous, individually separated by the spindled cells of the leiomyosarcoma. (A HE 100×, b HE 400× magnification. c Tumor cells and OGCs staining negative for cytokeratin AE1/AE3 (400×). d, e Representative images for SMA (d, 400×) and CD44 (e, 400×). f OGCs staining positive for CD68 (400×))

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