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Table 3 Treatment of brain metastases from colorectal cancer

From: Prognostic factors of brain metastases from colorectal cancer

Initial treatment period First half 1997–2005 Second half 2006–2015 p value
Treatment of brain metastases
 WBRT or WBRT + SRT 21 (58%) 3 (9%) 0.004
 SRT 4 (11%) 13 (41%)  
 Surgery + SRT 3 (8%) 4 (13%)  
 Surgery or Surgery + WBRT 4 (11%) 9 (28%)  
 Supportive care 4 (11%) 3 (9%)  
Regimen before diagnosis of brain metastases
 None 13 (36%) 9 (28%) 0.011
 Fluoropyrimidine only 9 (25%) 4 (13%)  
 Fluoropyrimidine + oxaliplatin 2 (6%) 4 (13%)  
 Fluoropyrimidine + irinotecan 6 (17%) 0 (0%)  
 Fluoropyrimidine + oxaliplatin + irinotecan 6 (17%) 15 (46%)  
Targeted agents
 Not used 34 (94%) 11 (34%) <.0001
 Used 2 (6%) 21 (66%)  
  1. WBRT Whole brain radiotherapy, SRT Stereotactic radiotherapy