Prognostic factors of brain metastases from colorectal cancer

BMC Cancer

Table 2 Univariate and multivariate analyses of factors affecting survival in patients with brain metastases from colorectal cancer

Variable	Category	Median overall survival (months)	Univariate analysis p value	Multivariate analysis
Variable	Category	Median overall survival (months)	Univariate analysis p value	Hazard ratio	95% CI	p value
Age at the time of brain metastases (years)	< 65	6.1 (3.1–10.5)	0.913	ref		0.963
Age at the time of brain metastases (years)	≥65	7.3 (4.6–10.9)	0.913	1.01	0.57–1.82	0.963
Karnofsky performance status score	≥70	6.8 (2.9–12.1)	0.384	ref		0.045
Karnofsky performance status score	< 70	6.8 (4.4–10.5)	0.384	1.88	1.02–3.59	0.045
Presence of extracranial metastases	Absent (Brain only)	9.7 (3.2–16.3)	0.507	ref		0.943
Presence of extracranial metastases	Present (Brain and other sites)	6.7 (3.2–8.8)	0.507	1.03	0.43–2.05	0.943
Control of primary tumor	Controlled	6.8 (4.6–9.7)	0.941	ref		0.979
Control of primary tumor	Uncontrolled	6.1 (1.3–39.6)	0.941	1.01	0.44–2.18	0.979
Number of brain metastases	Limited: 1–3	8.8 (6.1–12.1)	0.003	ref		0.033
Number of brain metastases	Multiple: ≥4	3.1 (1.4–7.3)	0.003	2.04	1.06–3.97	0.033
History of systemic chemotherapy before brain metastases	No	10.9 (6.1–25.4)	0.003	ref		0.006
History of systemic chemotherapy before brain metastases	Yes	6.8 (3.1–7.3)	0.003	2.39	1.28–4.68	0.006

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