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Table 2 Univariate and multivariate analyses of factors affecting survival in patients with brain metastases from colorectal cancer

From: Prognostic factors of brain metastases from colorectal cancer

Variable Category Median overall survival (months) Univariate analysis
p value
Multivariate analysis
Hazard ratio 95% CI p value
Age at the time of brain metastases (years) < 65 6.1 (3.1–10.5) 0.913 ref   0.963
≥65 7.3 (4.6–10.9) 1.01 0.57–1.82
Karnofsky performance status score ≥70 6.8 (2.9–12.1) 0.384 ref   0.045
< 70 6.8 (4.4–10.5) 1.88 1.02–3.59
Presence of extracranial metastases Absent (Brain only) 9.7 (3.2–16.3) 0.507 ref   0.943
Present (Brain and other sites) 6.7 (3.2–8.8) 1.03 0.43–2.05
Control of primary tumor Controlled 6.8 (4.6–9.7) 0.941 ref   0.979
Uncontrolled 6.1 (1.3–39.6) 1.01 0.44–2.18
Number of brain metastases Limited: 1–3 8.8 (6.1–12.1) 0.003 ref   0.033
Multiple: ≥4 3.1 (1.4–7.3) 2.04 1.06–3.97
History of systemic chemotherapy before brain metastases No 10.9 (6.1–25.4) 0.003 ref   0.006
Yes 6.8 (3.1–7.3) 2.39 1.28–4.68
  1. Data are presented as median (95% CI) or hazard ratio (95% CI)
  2. CI Confidence interval