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Table 2 Univariate and multivariate analysis of factors associated with OS of patients in the training cohort

From: Overall survival in patients over 40 years old with surgically resected pancreatic carcinoma: a SEER-based nomogram analysis

Variable Variable level Univariate analysis Multivariate analysis
HR 95%CI p-value HR 95%CI p-value
Age < 60 Reference    Reference   
≥60 1.517 1.370~1.680 < 0.001 1.328 1.198~1.471 < 0.001
Gender Male Reference      NI
Female 0.968 0.888~1.056 0.470    
Tumor Location in pancreas Head Reference    Reference   
Body 0.607 0.513~0.719 < 0.001 0.875 0.737~1.038 0.124
Tail 0.507 0.438~0.588 < 0.001 0.737 0.634~0.857 < 0.001
Grade Well Reference    Reference   
Moderately 3.495 2.983~4.094 < 0.001 2.616 2.224~3.078 < 0.001
Poorly 5.210 4.437~6.118 < 0.001 3.584 3.034~4.233 < 0.001
Undifferentiated 4.274 3.001~6.086 < 0.001 3.385 2.371~4.832 < 0.001
AJCC TNM stage I Reference    Reference   
II 3.661 3.081~4.351 < 0.001 1.855 1.542~2.231 < 0.001
Regional lymph nodes surgery None Reference      NI
1~3 1.477 0.600~3.638 0.396    
≥4 2.198 0.914~5.286 0.079    
Tumor size (cm) ≤2 Reference    Reference   
(2~4) 1.960 1.715~2.240 < 0.001 1.303 1.136~1.494 < 0.001
≥4 2.200 1.911~2.533 < 0.001 1.512 1.307~1.749 < 0.001
LNR ≤0.1732 Reference    Reference   
> 0.1732 1.991 1.821~2.176 < 0.001 1.522 1.388~1.669 < 0.001
  1. Abbreviations: OS overall survival, AJCC American Joint Committee on Cancer, TNM Tumor-Node-Metastasis, LNR lymph node