Long-term outcomes after surgical dissection of inguinal lymph node metastasis from rectal or anal canal adenocarcinoma

Table 2 Univariate and multivariate analyses of factors affecting survival in rectal or anal canal cancer patients with inguinal lymph node metastases

Variable	Category		Median overall survival (months)	Univariate analysis p value	Multivariate analysis
Variable	Category		Median overall survival (months)	Univariate analysis p value	Hazard ratio	95% CI	p value
Sex	Male		54.1	0.160
Sex	Female		241.9
Age, years	< 65		120.6	0.565
Age, years	≥65		66.6
Location of primary tumor	Rectum		120.6	0.305	Reference
Location of primary tumor	Anal canal		54.1		2.01	0.65–7.12	0.230
Pathological T stage	T1, 2, 3		66.6	0.806
Pathological T stage	T4		121.7
Tumor size, cm	< 5		49.1	0.745	Reference
Tumor size, cm	≥5		121.7		0.51	0.16–1.59	0.247
Mesorectal lymph node metastases	No		120.1	0.409	Reference
Mesorectal lymph node metastases	Yes		54.1		2.06	0.56–7.08	0.262
Lateral lymph node metastases	No		241.9	0.025	Reference
Lateral lymph node metastases	Yes		45.3		4.48	1.42–15.28	0.011
Distant metastases	M0		120.6	0.811
Distant metastases	M1		54.1
Histology	Well/moderately differentiated		120.6	0.027	Reference
Histology	Poorly differentiated/mucinous		10.4		7.99	1.61–43.01	0.012
Number of positive inguinal LNs	< 3	(n = 21)	121.7	0.159
Number of positive inguinal LNs	≥3	(n = 10)	51.5
Site of inguinal LN metastases	Unilateral	(n = 26)	120.6	0.678
Site of inguinal LN metastases	Bilateral	(n = 5)	51.6
Timing of inguinal LN metastases	Synchronous	(n = 14)	49.1	0.236	Reference
Timing of inguinal LN metastases	Metachronous	(n = 17)	120.6		0.31	0.09–1.03	0.056

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