Investigating the effects of additional truncating variants in DNA-repair genes on breast cancer risk in BRCA1-positive women

Table 2 Histopathological characteristics of tumors

	Early AAO cohort Number (%)	Affected controls Number (%)	P value
Histological Type Data available	62 out of 73	22 out of 25
Ductal	53 (85 .5%)	22 (100%)	0.10
Medullary	6 (9.7%)	0
Lobular	2 (3.2%)	0
Others	1 (1.6%)	0
Histological grade Data available	66 out of 73	22 out 25
Grade III	53 (80.3%)	14 (63.7%)	0.24
Grade II	13 (19.7%)	7 (31.8%)
Grade I	0	1 (4.5%)
Steroid receptors Data available	64 out of 73	22 out 25
ER negative	47 (73.4%)	13 (59.1%)	0.28
PR negative	52 (81.3%)	17 (77.3%)	0.76
Human Epidermal Receptor Data available	52 out of 73	19 out of 25
HER2/neu negative	49 (94.2%)	17 (89.5%)	0.60
Triple Negative Breast Cancer Data Available	55 out of 73	20 out of 25
TNB	32 (58.2%)	11 (55%)

Data were available for 67 out of 73 patients in the early age at onset cohort and from 25 cases that developed breast cancer in control cohort
ER Estrogen receptor, PR Progesterone receptor, HER2 Human epidermal growth factor receptor 2

ISSN: 1471-2407