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Table 2 Histopathological characteristics of tumors

From: Investigating the effects of additional truncating variants in DNA-repair genes on breast cancer risk in BRCA1-positive women

  Early AAO cohort
Number (%)
Affected controls
Number (%)
P value
Histological Type
Data available
62 out of 73 22 out of 25  
 Ductal 53 (85 .5%) 22 (100%) 0.10
 Medullary 6 (9.7%) 0  
 Lobular 2 (3.2%) 0  
 Others 1 (1.6%) 0  
Histological grade
Data available
66 out of 73 22 out 25  
 Grade III 53 (80.3%) 14 (63.7%) 0.24
 Grade II 13 (19.7%) 7 (31.8%)  
 Grade I 0 1 (4.5%)  
Steroid receptors
Data available
64 out of 73 22 out 25  
 ER negative 47 (73.4%) 13 (59.1%) 0.28
 PR negative 52 (81.3%) 17 (77.3%) 0.76
Human Epidermal Receptor
Data available
52 out of 73 19 out of 25  
 HER2/neu negative 49 (94.2%) 17 (89.5%) 0.60
Triple Negative Breast Cancer
Data Available
55 out of 73 20 out of 25  
 TNB 32 (58.2%) 11 (55%)  
  1. Data were available for 67 out of 73 patients in the early age at onset cohort and from 25 cases that developed breast cancer in control cohort
  2. ER Estrogen receptor, PR Progesterone receptor, HER2 Human epidermal growth factor receptor 2
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