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Table 3 Comparison of single protein classifiers with median as cut-offa

From: Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung

CEACAM5

 Specificity

1.00

 

Low

High

 

 Sensitivity

0.26

Benign

68

0

True

 PPV

1.00

LAC

113

31

outcome

 NPV

0.38

 

Predicted outcome

 

 Accuracy

0.47

    

CXCL17

 Specificity

0.66

 

Low

High

 

 Sensitivity

0.60

Benign

45

23

True

 PPV

0.79

LAC

58

86

outcome

 NPV

0.44

 

Predicted outcome

 

 Accuracy

0.62

    

VEGFR2

  

Low

High

 

 Specificity

0.35

Benign

24

44

True

 Sensitivity

0.40

LAC

87

57

outcome

 PPV

0.56

 

Predicted outcome

 

 NPV

0.22

    

 Accuracy

0.38

    

ERBB3

  

Low

High

 

 Specificity

0.40

Benign

36

54

True

 Sensitivity

0.44

LAC

81

63

outcome

 PPV

0.54

 

Predicted outcome

 

 NPV

0.31

    

 Accuracy

0.42

    
  1. aThe median protein level was used as cut-off (high vs low) to determine group affiliation
  2. PPV Positive predictive value, NPV Negative predictive value, LAC Lung adenocarcinoma
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BMC Cancer

ISSN: 1471-2407

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