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Fig. 4 | BMC Cancer

Fig. 4

From: Mechanisms of doxorubicin-induced drug resistance and drug resistant tumour growth in a murine breast tumour model

Fig. 4

a Protein expression of p21 and MCM2 between the TC, LD-DXR and HD-DXR groups (n = 8). * - significantly different compared to TC group (p < 0.05). Representative images of p16 and p53 protein expressions between the TC, LD-DXR and HD-DXR groups (n = 8). b Representative images of p21-FITC signal and localisation in tumour tissues following DXR treatment (n = 8). Hoechst 33342 – nuclei; FITC – p21; solid arrows – localised areas of intense signal in nuclei; dashed arrows- localised areas of intense signal in cytoplasm; scale = 20 μm, 40x objective

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