Fig. 3

a Protein expression of PDGFRα and p-ERK/ERK between the TC, LD-DXR and HD-DXR groups (n = 8). * - significantly different compared to TC group (p < 0.05). Representative images of p-cRaf, cRaf, p-p38, p38, p-JNK and JNK protein expressions between the TC, LD-DXR and HD-DXR groups (n = 8). b Representative images of p-PTEN, PTEN, p-PI3Kp85, PI3Kp85, p-PDK1, PDK1, p-Akt thr308, p-Akt ser473, Akt, p-mTOR and mTOR protein expressions between the TC, LD-DXR and HD-DXR groups (n = 8). c Representative images of p-ERK-FITC signal in tumour tissues following DXR treatment (n = 8). Hoechst 33342 – nuclei; FITC – p-ERK; solid arrows – localised areas of intense signal in cytoplasm; scale = 20 μm, 40x objective