Effects of DXR treatment on the average tumour volume (mm3). DXR treatment were initiated between day 6 and day 9. Three doses of DXR were administered three days apart. Error bars indicate the standard error of the mean (n = 15 (TC group), n = 16 (LD-DXR and HD-DXR groups)). The slope of the regression lines from the LD-DXR and HD-DXR groups were significantly different compared to the TC group.