BMC Cancer

Table 4 Univariate linear COX regression assessing associations between parameters from ¹⁸F-FDG PET/CT and patient prognosis

From: Volumetric parameters on ¹⁸F-FDG PET/CT predict the survival of patients with gastric cancer associated with their expression status of c-MET

Variables	PFS		OS
Variables	HR	P	HR	P
In all patients
Gender
Male	0.744	0.329	0.883	0.695
Female^a	1.000		1.000
Age (years)
≥ 62	1.506	0.164	1.143	0.660
< 62^a	1.000		1.000
Pathological types
WDA/MDA	1.252	0.447	1.103	0.749
PDA/MAC/SRC^a	1.000		1.000
Lauren classifications
Intestinal	0.925	0.809	0.853	0.635
Non-intestinal^a	1.000		1.000
Baseline CEA (ng/ml)
≥ 2.9	1.181	0.576	1.667	0.107
< 2.9^a	1.000		1.000
Baseline CA19–9 (U/ml)
≥ 9.0	1.537	0.162	1.632	0.138
< 9.0^a	1.000		1.000
Baseline CA72–4 (U/ml)
≥ 2.8	1.820	0.085	1.281	0.485
< 2.8^a	1.000		1.000
Findings on PET/CT
Distant metastasis	5.009	< 0.001	3.236	0.001
Locoregional^a	1.000		1.000
SUV_max	1.065	0.004	1.059	0.013
SUV_peak	1.079	0.005	1.071	0.017
MTV	1.005	0.031	1.005	0.055
TLG	1.001	0.031	1.001	0.072
In c-Met positive patients
SUV_max	1.054	0.037	1.063	0.013
SUV_peak	1.068	0.034	1.079	0.012
MTV	1.009	0.013	1.015	0.001
TLG	1.001	0.012	1.002	0.001
In c-Met negative patients
SUV_max	1.055	0.188	1.013	0.775
SUV_peak	1.071	0.161	1.015	0.799
MTV	1.002	0.631	0.999	0.788
TLG	1.000	0.897	0.999	0.478

Note. CA19–9 carbohydrate antigen 19–9, CA72–4 carbohydrate antigen 72–4, CEA carcinoembryonic antigen, WDA well differentiated adenocarcinoma, MDA moderate differentiated adenocarcinoma, PDA poorly differentiated adenocarcinoma, SRC signet-ring cell carcinoma, MAC mucinous adenocarcinoma, PET/CT positron emission tomography/computed tomography, SUV standardized uptake value, Max maximum, MTV metabolic tumor volume, TLG total lesion glycolysis, PFS progression free survival, OS overall survival, HR hazards ratio. ^a, reference group

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