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Table 1 Comparisons of clinicopathological variables and semi-quantitative parameters on 18F-FDG PET/CT between c-Met positive and negative patients

From: Volumetric parameters on 18F-FDG PET/CT predict the survival of patients with gastric cancer associated with their expression status of c-MET

Variables

Number (n = 61)

c-Met expression

P-values

Positive

Negative

Gender

 Male

41 (67.2%)

20 (60.6%)

21 (75.0%)

0.233

 Female

20 (32.8%)

13 (39.4%)

7 (25.0%)

 

Median age (range)

62 (36–81)

61 (36–74)

64 (38–81)

0.541#

Pathological types

 WDA

17 (27.9%)

12 (36.4%)

5 (17.9%)

0.373†

 MDA

18 (29.5%)

9 (27.3%)

9 (32.1%)

 

 PDA

21 (34.4%)

9 (27.3%)

12 (42.9%)

 

 MAC/SRC

5 (8.2%)

3 (9.1%)

2 (7.1%)

 

Lauren classifications

 Intestinal

23 (46.9%)

13 (48.1%)

10 (45.5%)

0.851†

 Non-intestinal

26 (53.1%)

14 (51.9%)

12 (54.5%)

 

Baseline CEA (ng/ml)

 Median (range)

2.9 (0.4–776.4)

2.9 (0.4–776.4)

3.1 (1.1–242.0)

0.399#

Baseline CA19–9 (U/ml)

   

 Median (range)

9.0 (0.6–597.4)

8.4 (0.6–597.4)

10.1 (0.6–69.2)

0.510#

Baseline CA72–4 (U/ml)

 Median (range)

2.8 (0.8–131.2)

3.2 (0.8–131.2)

2.0 (0.9–79.3)

0.288#

Findings on PET/CT

 Locoregional

26 (42.6%)

11 (33.3%)

15 (53.6%)

0.111

 Distant metastasis

35 (57.4%)

22 (66.7%)

13 (46.4%)

 

SUVmax (mean ± SD)

8.8 ± 6.40

9.6 ± 7.40

8.0 ± 4.91

0.335*

SUVpeak (mean ± SD)

7.2 ± 5.22

7.7 ± 5.99

6.6 ± 4.08

0.438*

MTV (mL, mean ± SD)

57.4 ± 54.39

70.8 ± 53.11

41.1 ± 52.32

0.034*

TLG (g, mean ± SD)

328.2 ± 417.44

428.4 ± 442.95

205.7 ± 354.40

0.039*

PFS, Median (95%CI)

14.5 (2.0–82.2)

11.5 (7.8–15.2)

17.6 (15.1–20.1)

0.039

OS, Median (95%CI)

20.0 (5–86.2)

17.0 (13.9–20.5)

24.3 (17.0–31.6)

0.043

  1. Note. SD standard deviation, CA19–9 carbohydrate antigen 19–9, CA72–4 carbohydrate antigen 72–4, CEA carcinoembryonic antigen, WDA well differentiated adenocarcinoma, MDA moderate differentiated adenocarcinoma, PDA poorly differentiated adenocarcinoma, SRC signet-ring cell carcinoma, MAC mucinous adenocarcinoma, PET/CT positron emission tomography/computed tomography, SUV standardized uptake value, Max maximum, MTV metabolic tumor volume, TLG total lesion glycolysis, PFS progression free survival, OS overall survival. *, Student’s t test; †, Chi square test; ‡, Kaplan-Meier analysis with the log-rank test; #, Mann-Whitney U test