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Table 5 Planned/ongoing trials registered in clinicaltrials.gov and ISRCTN databases

From: Dietary restriction during the treatment of cancer: results of a systematic scoping review

Trial Registration Trial design Participants (target recruitment number and type of cancer) Primary outcomes Planned start and end dates
Ketogenic Diets
 NCT03285152 Feasibility RCT 30 Endometrial No. of patients that complete the study Aug 2017- Aug 2019
 NCT02983942 Pilot RCT 50 Primary Central Nervous System Lymphoma No. and incidence of treatment related AEs Jan 2017 – Dec 2019
 SRCTN71665562 Pilot RCT 12 Glioblastoma Retention rate Jul 2016 – June 2019
 NCT02302235 RCT 42 Glioblastoma 1. Survival time
2. Time to progression (MRI assessed)
3. Incidence of AEs
Feb 2014 – Dec 2018
 NCT01754350 RCT 50 Glioblastoma Progression-free-survival rates 6 months after reirradiation May 2013 – June 2018
 NCT03278249 Feasibility trial (single arm) 30 Glioblastoma Ketosis (measured by serum BHB) Sep 2017 – Jan 2021
 NCT01865162 Pilot trial (single arm) 6 Glioblastoma Safety evaluation Jan 2013 – Jan 2019
 NCT01535911 Pilot trial (single arm) 16 Glioblastoma Brain tumour size response (MRI assessed) Apr 2012 – June 2019
 NCT03451799 Clinical trial (single arm) Glioblastoma Safety assessed by weight loss and AEs Apr 2018 – Sep 2020
 NCT02964806 Crossover trial 30 Pancreaticobiliary Cancer Diet intake rate Nov 2016 – Oct 2017
 NCT02939378 Non-randomised trial (2 arms) 60 Glioblastoma No. of participants with AEs Oct 2016 – Dec 2018
 NCT03535701 Non-randomised trial (2 arms) 15 Breast 1. Adherence
2. Change in psychosocial measures
3. Change in physiologic outcomes
Oct 2017 – Aug 2019
 NCT03194516 Observational 12 Prostate Weight loss at 8 weeks June 2017 – May 2021
Short-term Fast
 SRCTN17994717 Feasibility RCT 30 Colorectal Adherence, recruitment, retention and data completion rates
Acceptability and tolerability
Oct 2017 – Apr 2021
Fasting Mimicking Diets
 NCT02126449 RCT 250 Breast 1. Rate of grade 3/4 toxicity
2. Rate of pCR
Feb 2014 – Dec 2019
 NCT03700437 RCT 40 Lung Effect of diet on circulating tumour cells Oct 2018 – Dec 2020
 NCT03340935 Feasibility trial (single arm) 85 Any cancer AEs Feb 2017 – June 2018
 NCT03595540 Pilot trial (single arm) 60 Breast and colorectal 1. % diet consumed
2. Diet related AEs
Nov 2017 – Sep 2020
 NCT03454282 Clinical trial (single arm) 100 Breast and melanoma Change in peripheral blood mononuclear cell May 2018 – Dec 2020
Intermittent Fasts
 NCT03162289 RCT 150 Breast Change in FACT-G Quality of Life score May 2017 – May 2022
 NCT02710721 RCT 60 Prostate Change in FACT-P Quality of Life score April 2016 – Dec 2019
Ketogenic Diet combined with Short-Term Fast
 NCT02286167 Clinical trial (single arm) 25 Glioblastoma Multiforme Dietary adherence rates Nov 2014 – April 2019
  1. Abbreviations: AE Adverse Events, BHB Beta-hydroxybutyrate, MRI Magnetic Resonance Imaging, pCR Pathological Complete Response, RCT Randomised Controlled Trial