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Table 6 Accuracy of a positive risk score (> 10 points) to diagnose both ACN and CCR in the validation cohort (Phase II) and in the derivation plus validation cohorts (Phase I + Phase II). Frequency of colonoscopy prioritization with the associated miss of either CRC or AA cases for a Score > 10

From: Prediction of advanced colonic neoplasm in symptomatic patients: a scoring system to prioritize colonoscopy (COLONOFIT study)

PHASE II   
 ACNControl group (non-AA, non-CRC)Total
Score > 10118 (47 CCR)198316
Score ≤ 1030 (2 CCR)282312
Total148480628
 ACN CRC
Sensitivity (%)79 (72–85.4) 96 (85–99)
Specificity (%)58 (54.2–63) 52 (48–56)
PPV (%)37 (32–42.7) 14.4 (11–19)
NPV (%)90 (87–93.2) 99.3 (97–99.9)
Diagnostic OR5.6 (3.6–8.7) 25.4 (6.1–106)
LR (+)1.93 (1.7–2.2) 1.99 (1.8–2.2)
LR (−)0.34 (0.25–0.48) 0.08 (0.02–0.30)
Prevalence (%)23.6 7.8
Score ≤ 10N(%) Loss 
Missed cases of CRC24.1 
Missed cases of AA2828.3 
Score > 10N(%) Prioritization 
Prioritization31650.3 
PHASE I + PHASE II   
 ACNControl group
(non-AA, non-CRC
Total
Score > 10270 (114 CRC)468738
Score ≤ 1049 (2 CRC)708757
Total31911761495
 ACN CRC
Sensitivity (%)85 (80.3–88) 98 (93–99.7)
Specificity (%)60 (57.4–63) 53 (51–56)
PPV36 (33.2–40) 15 (13–18)
NPV93.5 (91.5–95) 99.7 (99–100)
Diagnostic OR8.3 (6–11.5) 65.2 (16–265)
LR (+)2.12 (1.95–2.31) 2.10 (1.98–2.24)
LR (−)0.25 (0.20–0.33) 0.03 (0.008–0.13)
Prevalence (%)21.3 7.76
Score ≤ 10N(%) Loss 
Missed cases of CRC21.7 
Missed cases of AA4723 
Score > 10N(%) Prioritization 
Prioritization73849.3 
  1. 95% CI