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Table 2 Univariate and age- and FIT-adjusted predictors of ACN in the derivation (Phase I) cohort: Crude and adjusted ORs, and C-Statistic and Brier score of the adjusted model

From: Prediction of advanced colonic neoplasm in symptomatic patients: a scoring system to prioritize colonoscopy (COLONOFIT study)

VARIABLEControl group
(Non-AA, non-CRC)
AA+CRCOR (Crude)
[95%CI]
OR (Adjusted)
[95%CI]
C-Statistic/ Brier score
adjusted model
 N = 696N = 171   
Gender
 Man311 (44.7%)103 (60.2%)Ref.Ref. 
 Woman385 (55.3%)68 (39.8%)0.53 [0.38;0.75]0.81 [0.53;1.21]0.841 / 0.1158
Body Mass Index (Kg/m2)
  ≤ 25246 (35.3%)47 (27.5%)Ref.Ref. 
  > 25450 (64.7%)124 (72.5%)1.44 [1.01;2.10]1.19 [0.77;1.85]0.841 / 0.1161
Colonoscopy (5 years before)
 No555 (79.7%)153 (89.5%)Ref.Ref. 
 Yes141 (20.3%)18 (10.5%)0.47 [0.27;0.77]0.35 [0.21;0.63]0.862 / 0.1031
Smoking (History)
 No359 (51.6%)77 (45.0%)Ref.Ref. 
 Yes (Ex/Current)337 (48.4%)94 (55.0%)1.30 [0.93;1.82]1.51 [1.02;2.29]0.859 / 0.1050
Smoking (Years):
 No359 (51.6%)77 (45.0%)Ref.Ref. 
  ≤ 42191 (27.4%)25 (14.6%)0.61 [0.37;0.98]1.17 [0.6;2.33] 
  > 42146 (21.0%)69 (40.4%)2.20 [1.51;3.21]1.65 [0.99;2.61]0.849 / 0.1086
Drugs (NSAIDs or antiplatelet or anticoagulants)
 No415 (59.6%)98 (57.3%)Ref.Ref. 
 Yes281 (40.4%)73 (42.7%)1.10 [0.78;1.54]0.79 [0.52;1.21]0.841 / 0.1153
Anticoagulants
 No673 (96.7%)156 (91.2%)Ref.Ref. 
 Yes23 (3.30%)15 (8.77%)2.82 [1.40;5.50]1.67 [0.75;3.80]0.842 / 0.1159
NSAIDs
 No525 (75.4%)136 (79.5%)Ref.Ref. 
 Yes171 (24.6%)35 (20.5%)0.79 [0.52;1.18]0.79 [0.49;1.29]0.846 / 0.1156
Abdominal pain
 No299 (43.0%)97 (56.7%)Ref.Ref. 
 Yes397 (57.0%)74 (43.3%)0.58 [0.41;0.81]0.77 [0.52;1.16]0.840 / 0.116
Iron deficiency
 No237 (34.1%)56 (32.7%)Ref.Ref. 
 Yes174 (25.0%)55 (32.2%)1.34 [0.88;2.04]0.92 [0.55;1.92] 
 Unknown285 (40.9%)60 (35.1%)0.89 [0.59;1.34]0.86 [0.54;1.37]0.840 / 0.116
Iron deficiency anaemia
 No371 (53.3%)77 (45.0%)Ref.Ref. 
 Yes166 (23.9%)54 (31.6%)1.57 [1.05;2.32]1.13 [0.69;1.84] 
 Unknown159 (22.8%)40 (23.4%)1.21 [0.79;1.85]1.14 [0.69;1.91]0.840 / 0.116
Type change bowel habit
 No261 (37.5%)78 (45.6%)Ref.Ref. 
 Diarrhoea226 (32.5%)59 (34.5%)0.87 [0.59;1.28]1.08 [0.68;1.71] 
 Constipation179 (25.7%)31 (18.1%)0.58 [0.36;0.91]0.71 [0.42;1.22] 
 Unknown30 (4.31%)3 (1.75%)0.35 [0.08;1.02]0.78 [0.23;2.74]0.840 / 0.1153
Abdominal pain duration
 No299 (43.0%)97 (56.7%)Ref.Ref. 
 Yes, 1–12 Days123 (17.7%)26 (15.2%)0.65 [0.40;1.05]0.65 [0.37;1.15] 
 Yes, > 12 Days274 (39.4%)48 (28.1%)0.54 [0.37;0.79]0.86 [0.54;1.37]0.850 / 0.1157
Rectal bleeding pattern
 No342 (49.1%)84 (49.1%)Ref.Ref. 
 Yes, without specific pattern219 (31.5%)43 (25.1%)0.80 [0.53;1.20]0.59 [0.36;1.07] 
 Yes, with specific pattern135 (19.4%)44 (25.7%)1.44 [0.97;2.12]1.33 [0.87;2.01]0.849 / 0.1151
Rectal bleeding duration (days)
 No rectal bleeding342 (49.1%)84 (49.1%)Ref.Ref. 
  ≤ 30328 (47.1%)74 (43.3%)0.92 [0.65;1.30]0.63 [0.41;1.05] 
  > 3026 (3.74%)13 (7.60%)2.04 [0.97;4.10]0.86 [0.37;1.98]0.846 / 0.1150
Haemoglobin (g/dL)
  ≤ 11105 (15.1%)43 (25.1%)Ref.Ref. 
  > 11481 (69.1%)112 (65.5%)0.57 [0.38;0.86]1.02 [0.61;1.71] 
 Unknown110 (15.8%)16 (9.36%)0.36 [0.18;0.67]0.62 [0.31;1.31]0.847 / 0.1127
Ferritin (ng/mL)
  ≤ 40176 (25.3%)56 (32.7%)Ref.Ref. 
  > 40225 (32.3%)53 (31.0%)0.74 [0.48;1.13]0.82 [0.51;1.34] 
 Unknown295 (42.4%)62 (36.3%)0.66 [0.44;0.99]0.85 [0.52;1.39]0.849 / 0.1106
CEA (ng/mL)
  ≤ 12610 (87.6%)135 (78.9%)Ref.Ref. 
  > 125 (0.72%)11 (6.43%)9.73 [3.43;32.1]2.91 [0.88;9.36] 
 Unknown81 (11.6%)25 (14.6%)1.40 [0.85;2.25]1.27 [0.71;2.27]0.849 / 0.1101