Table 1 Criteria for dose suspension or reduction

Neutrophil count (with preventive treatment by G-CSF^a)

Grade 4 (lasting for 5 days or more)

Preventive treatment by G-CSF.

Neutrophil count (without preventive treatment by G-CSF)

Grade 4 (lasting for 5 days or more)

Reduced dose of 720 mg/m2 of GEM^a and 55mg/m2 of DTX^a (first occurrence), then 570 mg/m2 of GEM and 44mg/m2 of DTX (second occurrence).

Diarrhea

Grade 3

Mucositis oral

Grade 3

Infection

Grade 3

Pneumonitis

Grade 1

Grade 2

Discontinue protocol treatment.

Neuropathy

Grade 2

Reduced dose of 720 mg/m2 of GEM and 55mg/m2 of DTX (first occurrence), then 570 mg/m2 of GEM and 44mg/m2 of DTX (second occurrence).

Grade 3

Discontinue protocol treatment.

Creatinine

Grade 2-4

Supraventricular tachycardia

Grade 2 (two times), Grade 3

Atrial arrhythmia

Grade 2 (two times), Grade 3

Left ventriclar contractile dysfunction

Grade 2 (two times), Grade 3

Vertigo/Dizziness

Grade 2-3

Depressed level of consciousness

Grade 2-3

Seizure

Grade 2-3

Leukoencephalopathy

Grade 2-3

Non-hematological toxicity

Grade 4