Hyperprogression after immunotherapy in patients with malignant tumors of digestive system

BMC Cancer

Table 2 The related parameters of hyperprogression according to different researchers

	Champiat et al. [8]	Kato et al. [9]	Saada-Bouzid et al. [10]
Evaluation criteria	RECIST 1.1	irRC	RECIST 1.1 irRECIST
Tumor growth dynamics indicator	TGR	PP	TGK
Specific formula	TG = 3Log(S_T /S₀) /(T-T₀) TGR = 100(TG-1)	PP = (S_T -S₀) /S₀	TGK = (S_T -S₀) /(T-T₀)
Definition of hyperprogression	PD TGR_POST /TGR_PRE ≥ 2	TTF < 2 months S_POST /S_PRE ≥ 150% PP_POST /PP_PRE > 2	TGK_POST /TGK_PRE ≥ 2

T and T₀ stand for two time points respectively. S_T and S₀ stand for the sum of tumor burden at T and T₀ respectively. TGR_PRE stands for the TGR calculated between pre-baseline and baseline, TGR_POST stands for the TGR calculated between baseline and first evaluation imaging. And the other subscripts of “PRE” and “POST” have the similar meanings. Abbreviation: TGR, tumor growth rate; PP, progression pace; TGK, tumor growth kinetics; PD, progressed disease; TTF, time to treatment failure

ISSN: 1471-2407