Table 1 Correlation between Pin1, RhoA and RhoC expression and clinicopathological parameters of the HCC patients in this study The median, lower quartile and upper quartile of the relative expression of each gene (fold to actin) of different experimental group were shown. Rank Sum test was performed to compare the difference

Pin1

0.039 (0.004–0.074)

0.023 (0.001–0.095)

0.317

RhoA

0.558 (0.101–1.264)

0.479 (0.121–1.675)

0.871

RhoC

0.182 (0.066–0.677)

0.314 (0.096–0.751)

0.364

Age

≤55

> 55

p-value

Pin1

0.004 (0.000–0.048)

0.058 (0.005–0.151)

<0.001

RhoA

0.189 (0.076–0.617)

0.941 (0.167–2.518)

< 0.001

RhoC

0.141 (0.056–0.355)

0.460 (0.129 0.897

<0.001

HBsAg

negative

positive

p-value

Pin1

0.058 (0.002–0.095)

0.020 (0.001–0.096)

0.284

RhoA

0.680 (0.121–1.936)

0.408 (0.117–1.567)

0.670

RhoC

0.356 (0.112–0.737)

0.255 (0.090–0.774)

0.966

Cirrhosis

negative

positive

p-value

Pin1

0.011 (0.001–0.075)

0.044 (0.003–0.096)

0.143

RhoA

0.346 (0.103–1.433)

0.790 (0.126–1.807)

0.308

RhoC

0.238 (0.095–0.760)

0.383 (0.086–0.654)

0.678

Tumor size

≤5

> 5

p-value

Pin1

0.045 (0.006–0.113)

0.008 (0.001–0.074)

0.021

RhoA

0.913 (0.189–1.654)

0.245 (0.099–1.354)

0.061

RhoC

0.433 (0.165–0.778)

0.187 (0.080–0.627)

0.048

Stage

low

high

p-value

Pin1

0.006 (0.001–0.061)

0.060 (0.018–0.152)

<0.001

RhoA

0.217 (0.101–0.944)

1.029 (0.306–2.750)

0.002

RhoC

0.187 (0.082–0.532)

0.470 (0.187–1.259)

0.003

Metastasis

absent

present

p-value

Pin1

0.006 (0.008–0.065)

0.065 (0.048–0.260)

<0.001

RhoA

0.210 (0.096–0.984)

1.746 (0.926–4.374)

<0.001

RhoC

0.188 (0.073–0.499)

0.763 (0.371–1.880)

<0.001

Recurrence

absent

present

p-value

Pin1

0.008 (0.001–0.051)

0.058 (0.003–0.150)

0.003

RhoA

0.189 (0.094–0.758)

1.137 (0.306–3.301)

<0.001

RhoC

0.132 (0.064–0.436)

0.501 (0.207–1.377)

<0.001