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Table 1 Correlation between Pin1, RhoA and RhoC expression and clinicopathological parameters of the HCC patients in this study The median, lower quartile and upper quartile of the relative expression of each gene (fold to actin) of different experimental group were shown. Rank Sum test was performed to compare the difference

From: Overexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients

Gender Male Female p-value
Pin1 0.039 (0.004–0.074) 0.023 (0.001–0.095) 0.317
RhoA 0.558 (0.101–1.264) 0.479 (0.121–1.675) 0.871
RhoC 0.182 (0.066–0.677) 0.314 (0.096–0.751) 0.364
Age ≤55 > 55 p-value
Pin1 0.004 (0.000–0.048) 0.058 (0.005–0.151) <0.001
RhoA 0.189 (0.076–0.617) 0.941 (0.167–2.518) < 0.001
RhoC 0.141 (0.056–0.355) 0.460 (0.129 0.897 <0.001
HBsAg negative positive p-value
Pin1 0.058 (0.002–0.095) 0.020 (0.001–0.096) 0.284
RhoA 0.680 (0.121–1.936) 0.408 (0.117–1.567) 0.670
RhoC 0.356 (0.112–0.737) 0.255 (0.090–0.774) 0.966
Cirrhosis negative positive p-value
Pin1 0.011 (0.001–0.075) 0.044 (0.003–0.096) 0.143
RhoA 0.346 (0.103–1.433) 0.790 (0.126–1.807) 0.308
RhoC 0.238 (0.095–0.760) 0.383 (0.086–0.654) 0.678
Tumor size ≤5 > 5 p-value
Pin1 0.045 (0.006–0.113) 0.008 (0.001–0.074) 0.021
RhoA 0.913 (0.189–1.654) 0.245 (0.099–1.354) 0.061
RhoC 0.433 (0.165–0.778) 0.187 (0.080–0.627) 0.048
Stage low high p-value
Pin1 0.006 (0.001–0.061) 0.060 (0.018–0.152) <0.001
RhoA 0.217 (0.101–0.944) 1.029 (0.306–2.750) 0.002
RhoC 0.187 (0.082–0.532) 0.470 (0.187–1.259) 0.003
Metastasis absent present p-value
Pin1 0.006 (0.008–0.065) 0.065 (0.048–0.260) <0.001
RhoA 0.210 (0.096–0.984) 1.746 (0.926–4.374) <0.001
RhoC 0.188 (0.073–0.499) 0.763 (0.371–1.880) <0.001
Recurrence absent present p-value
Pin1 0.008 (0.001–0.051) 0.058 (0.003–0.150) 0.003
RhoA 0.189 (0.094–0.758) 1.137 (0.306–3.301) <0.001
RhoC 0.132 (0.064–0.436) 0.501 (0.207–1.377) <0.001