Fig. 3From: Afatinib helped overcome subsequent resistance to osimertinib in a patient with NSCLC having leptomeningeal metastasis baring acquired EGFR L718Q mutation: a case reportDynamic changes in the allelic variations (a) and clinical factors (b). The y-axis represents the allelic fraction or amplification copy number, and the x-axis represents the treatment timeline. Each color represents a variant. CSF, Cerebrospinal fluid; ECOG, Eastern Cooperative Oncology Group; NRS, numeric rating scaleBack to article page