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Table 2 Clinical characteristics by EGFR mutation subtypes

From: Clinical outcome of treatment of metastatic non-small cell lung cancer in patients harboring uncommon EGFR mutation

 

Single mutation

Compound mutation

G719X (n = 4)

L861Q (n = 5)

Exon 20 Ins (n = 6)

Combine with uncommon mutation (n = 7)a

Del19 plus L858R (n = 2)

Combine with de novo T790 M (n = 4)

Median age (years)

72.5

69

68.5

68

59 and 80

65

Sex

 Female

1

1

4

2

0

2

 Male

3

4

2

5

2

2

Smoking history

 Yes

3

3

2

4

1

1

 No

1

2

4

3

1

3

Extra-pulmonary metastasis

 Yes

2

2

6

1

1

4

 No

2

3

0

3

1

0

Present of CNS metastasis

 Yes

1

1

0

1

0

2

 No

3

4

6

6

2

2

  1. a4 of G719X plus S768I, 1 of G719X plus E709A, 1 of L858R plus Exon20Ins and 1 of del19 plus KRAS mutant