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Table 4 Crude and adjusted analysis of the association between age and preoperative radiotherapy in stage II and III rectal cancer patients

From: Impact of age on the use of adjuvant treatments in patients undergoing surgery for colorectal cancer: patients with stage III colon or stage II/III rectal cancer

 Preoperative radiotherapy in stage II and III rectal cancer
4A. Univariate analysis4B. Multivariate analysis
n (%)P valueOdds Ratio (95% CI)P value
Age, years
  < 65138 (68.0)< 0.0005b1 
 65–80142 (60.4) 0.9 (0.6–1.4)0.74
  > 8027 (42.2) 0.5 (0.3–0.8)0.004
Sex
 Male205 (60.7)0.85a  
 Female102 (61.8)   
Deprivation index
 Quartile 150 (61.7)0.31b  
 Quartile 286 (54.8)   
 Quartile 394 (61.8)   
 Quartile 457 (65.5)   
Level of education
 No formal31 (62.0)0.78b  
 Primary164 (60.5)   
 Secondary28 (65.1)   
 University25 (55.6)   
Living arrangements
 Living alone30 (60.0)0.88a  
 Living with others217 (61.3)   
Family history of cancer
 No147 (55.3)0.005a1 
 Yes136 (68.3) 1.5 (1.0–2.1)0.05
Screening
 No262 (61.6)0.30a  
 Yes29 (53.7)   
Smoking habits
 Never smoker136 (60.7)0.31a  
 Current smoker56 (68.3)   
 Ex-smoker113 (58.5)   
Alcohol
 No264 (61.4)0.77a  
 Yes32 (59.3)   
Charlson index
 0179 (64.6)0.03b1 
 174 (60.7) 0.9 (0.6–1.4)0.77
  ≥ 254 (51.9) 0.9 (0.5–1.7)0.88
ASA class
 I-II187 (63.8)0.12b1 
 III106 (57.6) 0.9 (0.6–1.2)0.39
 IV7 (50.0) 0.8 (0.3–2.4)0.68
Degree of differentiation
 Low grade201 (59.5)0.76a  
 High grade29 (56.9)   
Histological classification
 Adenocarcinoma268 (60.8)0.29a  
 Mucinous adenocarcinoma13 (52.0)   
Stage
 II75 (45.7)< 0.0005a1 
 III232 (68.4) 2.8 (1.5–4.9)0.001
Cancer committee
 No84 (57.9)0.48a  
 Yes205 (61.6)   
Surgeon’s profile
 General91 (61.1)1.0a  
 Coloproctologist201 (61.3)   
  1. aPearson Chi-square test
  2. bChi-square test for trends