Skip to main content
Fig. 4 | BMC Cancer

Fig. 4

From: The design, analysis and application of mouse clinical trials in oncology drug development

Fig. 4

Survival analysis in a cisplatin MCT. (a) The median progression free survival (PFS) times of PDXs under cisplatin and vehicle treatment are highly correlated. The dotted line is the linear regression lines, and the solid line is a line with unit slope. (b) The first frailty term ui in Eq. 5 is positively correlated with the tumor growth rate kc. (c) Survival curves under cisplatin and vehicle treatments. Additive frailty model gives more accurate hazard ratio (HR) than the Cox proportional hazards model whose estimation is 0.36 (95% CI: 0.28–0.46). (d) Statistical power curves at significance level α = 0.05 when the hazard ratio is 0.9 to 0.1 for the survival analysis. The 10 colored curves in each graph denote the number of mice per PDX per arm

Back to article page