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Fig. 3 | BMC Cancer

Fig. 3

From: The design, analysis and application of mouse clinical trials in oncology drug development

Fig. 3

Linear mixed models (LMMs) can be used to model the clustered longitudinal data from MCTs. (a) the structure of the clustered longitudinal data for a PDX in a MCT. PDX level and mouse level covariates can be incorporated into LMMs. (b) Mean tumor growth curves for 3 cancers under vehicle treatment and cisplatin treatment. (c) Statistical power curves of the cisplatin MCT. Power is calculated at significance level α = 0.05 when the cisplatin treatment reduces tumor growth rate by 10 to 90%, i.e. β12 = − 0.1 to − 0.9 in Eq. 4 in Materials and Methods. The 10 colored curves in each graph denote the number of mice for every PDX in each arm

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