Fig. 3
From: The design, analysis and application of mouse clinical trials in oncology drug development
Linear mixed models (LMMs) can be used to model the clustered longitudinal data from MCTs. (a) the structure of the clustered longitudinal data for a PDX in a MCT. PDX level and mouse level covariates can be incorporated into LMMs. (b) Mean tumor growth curves for 3 cancers under vehicle treatment and cisplatin treatment. (c) Statistical power curves of the cisplatin MCT. Power is calculated at significance level α = 0.05 when the cisplatin treatment reduces tumor growth rate by 10 to 90%, i.e. β1/β2 = − 0.1 to − 0.9 in Eq. 4 in Materials and Methods. The 10 colored curves in each graph denote the number of mice for every PDX in each arm