Fig. 2

Determining mouse numbers for continuous responses. (a-c): Progression-free survival, or PFS, calculated from n mice (n = 1 to 9) randomly sampled from a unique treatment model with at least 10 mice shows relative deviation to the PFS calculated from all mice in PDX (a), CDX (b), and syngeneic models (c), x axis is the percent error of PFS, and y axis is the empirical cumulative density function (ECDF) estimated from the random samplings for each n. Percent error of PFS decreases with increased number of mice, and the error is larger for syngeneic models than PDXs/CDXs. (d): Percentages of unique treatment models with percent error less than 20% in the 3 types of mouse models. (e-g): RTV ratio between drug and vehicle groups, calculated from n mice (n = 1 to 9) randomly sample from a study with at least 10 mice in both drug and vehicle groups, shows deviation to the RTV ratio calculated from all mice in both groups in PDX (e), CDX (f), and syngeneic models (g), x axis is the absolute error, and y axis is the empirical cumulative density function (ECDF) estimated from the random samplings for each n. Absolute error of RTV ratio decreases with increased number of mice, and the error is larger for syngeneic models than PDXs/CDXs. (h): Percentages of studies with absolute error less than 0.2 in the 3 types of mouse models