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Table 3 Mean values at baseline, and between-group differences and at the end of chemotherapy, the end of radiotherapy and at 6-month and 1-year follow-up for muscular, body composition and attentional outcomes

From: Short- and long-term impact of adapted physical activity and diet counseling during adjuvant breast cancer therapy: the “APAD1” randomized controlled trial

 T0 BaselineT1–18 weeks
Mid-intervention
T2–26 weeks
End of intervention
T3–52 weeks
6-month follow-up
T4–78 weeks
1-year follow-up
Mean (SD)AMD (95% CI)*EFPAMD (95% CI)*EFPAMD (95% CI)*EFPAMD (95% CI)*EFP
Muscular tests
Sit-and-stand 30sUC16.4 (4.9)0.07 (0.02; 0.12)0.250.0050.04 (−0.03; 0.11)0.090.2030.07 (−0.03; 0.17)0.120.125
APAD15.3 (3.7)            
Sit-and-stand ratioUC0.95 (0.12)0.04 (0.01; 0.08)0.220.0130.036 (−0.007; 0.078)0.140.0810.01 (− 0.05; 0.06)0.020.563
APAD0.92 (0.11)            
Power ratioUC0.94 (0.14)−0.01 (− 0.06; 0.04)0.090.541−0.07 (− 0.13; − 0.01)−0.190.041−0.02 (− 0.1; 0.06)− 0.050.508
APAD0.96 (0.15)            
Force ratioUC0.99 (0.14)0.00 (−0.04; 0.04)0.010.978−0.02 (− 0.07; 0.04)− 0.050.529−0.04 (− 0.11; 0.03)− 0.090.313
APAD1.00 (0.15)            
Attentional performances (TAP)
Alertness indexUC−0.002 (0.099)− 0.01 (− 0.04; 0.01)−0.090.3590.00 (−0.03; 0.04)0.020.9180.01 (−0.04; 0.06)0.040.700
APAD0.010 (0.069)            
Flexibility indexUC6.7 (9.4)2.58 (0.54; 4.62)0.210.0440.281 (−2.46; 3.03)0.020.8410.972 (−2.49; 4.44)0.050.594
APAD7.2 (9)            
Flexibility: errorsUC2 (4.1)−0.29 (−0.48; − 0.09)− 0.240.024−0.05 (− 0.32; 0.22)− 0.030.741−0.023 (− 0.38; 0.34)− 0.010.898
APAD1.8 (3.4)            
Working memory: errors - omissionsUC5.9 (6.5)−0.06 (−0.26; 0.14)−0.050.9150.14 (−0.16; 0.43)0.080.217−0.113 (− 0.51; 0.28)− 0.050.854
APAD3.7 (4.1)            
Anthropometry and body composition
Weight (kg)UC69.7 (14.1)−0.44 (−1.27; 0.39)−0.090.576−1.19 (−2.13; −0.25)−0.210.051−0.45 (−1.8; 0.91)−0.050.680−0.52 (−2.33; 1.29)−0.050.690
APAD67.5 (13.8)            
BMI (kg/m2)UC25.8 (5.3)−0.17 (−0.48; 0.15)−0.090.515−0.46 (− 0.82; − 0.11)−0.210.033−0.16 (− 0.66; 0.34)− 0.050.664−0.17 (− 0.84; 0.49)− 0.040.706
APAD25.3 (5.4)            
FM (%)UC32.9 (7.7)−1.10 (−1.97; − 0.22)−0.210.041− 0.27 (− 1.53; 1.00)− 0.030.717− 0.35 (−2.05; 1.35)− 0.030.708
APAD33.1 (7.7)            
MM (kg)UC45.4 (5.4)−0.16 (−0.65; 0.33)−0.050.7410.33 (−0.36; 1.02)0.080.2790.56 (−0.34; 1.47)0.100.174
APAD44.2 (4.9)            
MM to FM ratio§UC0.5 (0.2)0.03 (0; 0.07)0.170.0930.02 (−0.03; 0.07)0.060.4690.01 (− 0.06; 0.08)0.020.836
APAD0.5 (0.2)            
FM - trunk (kg)UC12.2 (5.6)−0.88 (−1.49; − 0.27)− 0.240.027−0.02 (− 0.85; 0.8)0.000.985−0.23 (− 1.28; 0.83)− 0.040.734
APAD12.2 (5.4)            
MM - trunk (kg)UC23.4 (2.9)− 0.13 (− 0.37; 0.11)− 0.090.4680.02 (−0.32; 0.37)0.010.7790.06 (−0.4; 0.52)0.020.689
APAD22.9 (2.6)            
FM - legs (kg)§UC8.7 (2.9)−0.06 (−0.11; − 0.01)− 0.200.0710.02 (−0.05; 0.09)0.040.5550.01 (−0.08; 0.1)0.020.734
APAD8.4 (3)            
MM - legs (kg)UC16.5 (1.9)0.00 (− 0.21; 0.21)0.000.7430.30 (0.00; 0.59)0.170.0380.40 (0.01; 0.79)0.170.032
APAD16 (1.7)            
  1. Abbreviations: AMD Adjusted Mean Differences, EF Effect Size of difference between groups, CI Confidence Interval, TAP Test of Attentional Performance, APAD Adapted Physical Activity and Diet counseling intervention, UC Usual Care, FM Fat Mass, MM Muscle mass
  2. NOTE: Bold font indicates significant difference. T1 columns contain empty cells because muscular, body composition and attentional outcomes were not measured at T1, except weight and BMI
  3. *Baseline value, surgery type and age-adjusted mean differences and their associated 95% confidence interval estimated with linear mixed model
  4. P-value for time*arm interaction estimated with linear mixed model
  5. Log transformed variables: Sit-and-stand 30s, Flexibility: errors – TAP, Working memory: errors and omissions – TAP
  6. §Square root transformed variables: Muscle to fat mass ratio, Fat mass - legs only