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Table 5 OS Multivariate Analysis

From: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictive and prognostic markers in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiation

Outcome

Hazard Ratio (95% CI)

P-value

NLR

 < 4

ref

0.99

 ≥ 4

1.00 (0.76–1.32)

 

PLR

 < 150

ref

0.59

 ≥ 150

0.99 (0.76–1.29)

 

Pre-treatment CEA

 < 5 ng/ml

ref

< 0.01

 ≥ 5 ng/ml

1.71 (1.33–2.20)

 

 Unknown

1.64 (1.13–2.38)

ECOG Performance Status

< 0.01

 0

ref

 

 1

1.43 (1.06–1.92)

 2+

2.24 (1.41–3.56)

 Unknown

1.29 (0.90–1.85)

Age at diagnosis

 < 65

ref

< 0.01

 ≥ 65

1.50 (1.18–1.90)

 
  1. CEA Carcinoembryonic antigen, ECOG Eastern Cooperative Oncology Group, NLR Neutrophil-to-lymphocyte ratio, OS Overall survival, PLR Platelet-to-lymphocyte ratio