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Table 5 OS Multivariate Analysis

From: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictive and prognostic markers in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiation

Outcome Hazard Ratio (95% CI) P-value
NLR
 < 4 ref 0.99
 ≥ 4 1.00 (0.76–1.32)  
PLR
 < 150 ref 0.59
 ≥ 150 0.99 (0.76–1.29)  
Pre-treatment CEA
 < 5 ng/ml ref < 0.01
 ≥ 5 ng/ml 1.71 (1.33–2.20)  
 Unknown 1.64 (1.13–2.38)
ECOG Performance Status < 0.01
 0 ref  
 1 1.43 (1.06–1.92)
 2+ 2.24 (1.41–3.56)
 Unknown 1.29 (0.90–1.85)
Age at diagnosis
 < 65 ref < 0.01
 ≥ 65 1.50 (1.18–1.90)  
  1. CEA Carcinoembryonic antigen, ECOG Eastern Cooperative Oncology Group, NLR Neutrophil-to-lymphocyte ratio, OS Overall survival, PLR Platelet-to-lymphocyte ratio