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Table 2 Treatment details

From: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictive and prognostic markers in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiation

Variable   Total (N = 1237) NLR p-val PLR p-val
<  4 (n = 912, 74%) ≥ 4 (n = 325, 26%) <  150 (n = 418, 34%) ≥ 150 (n = 819, 66%)
Neoadjuvant chemotherapy, n (%) 5-fluorouracil 764 (62) 558 (61) 206 (63) NS 256 (61) 508 (62) NS
Capecitabine 430 (35) 322 (35) 108 (33)   149 (36) 281 (34)  
Raltitrexed 15 (1) 14 (1) 1 (0)   5 (1) 10 (1)  
Unknown 28 (2) 18 (2) 10 (3)   8 (2) 20 (3)  
Radiotherapy dose (Gy), n (%) Median (range) 50 (20–80) 50 (20–74) 50 (29–80) NS 50 (20–74) 60 (22–80) NS
<  44 36 (3) 32 (3) 4 (1) 0.02 15 (4) 21 (3) NS
44–46 225 (18) 156 (17) 69 (21)   65 (15) 160 (19)  
≥ 46 966 (78) 719 (79) 247 (76)   333 (80) 633 (77)  
Unknown 10 (1) 5 (1) 5 (2)   5 (1) 5 (1)  
Time from nCRT completion to TME <  6 weeks 190 (15) 139 (15) 51 (16) NS 62 (15) 128 (16) NS
6–12 weeks 988 (80) 725 (80) 263 (81)   335 (80) 653 (80)  
>  12 weeks 57 (5) 46 (5) 11 (3)   20 (5) 37 (4)  
Unknown 2 (0) 2 (0) 0 (0)   1 (0) 1 (0)  
Adjuvant chemotherapy, n (%) 5-fluorouracil 214 (17) 159 (17) 55 (17) NS 78 (19) 136 (17) NS
Capecitabine 336 (27) 249 (27) 87 (27)   99 (24) 237 (29)  
5-fluorouracil / oxaliplatin 275 (22) 199 (22) 76 (23)   96 (23) 179 (22)  
Capecitabine / oxaliplatin 64 (5) 50 (5) 14 (4)   32 (8) 32 (4)  
Other 10 (1) 8 (1) 2 (1)   4 (0) 6 (1)  
No adjuvant chemotherapy 338 (27) 247 (27) 91 (28)   109 (26) 229 (28)  
Completed treatment as planned, n (%) Neoadjuvant radiotherapy 1171 (95) 859 (94) 312 (96) NS 394 (94) 777 (95) NS
Neoadjuvant chemotherapy 1001 (81) 734 (80) 267 (82) NS 333 (80) 668 (82) NS
Type of surgery, n (%) Low anterior resection 657 (53) 490 (54) 167 (51) NS 231 (55) 426 (52) NS
Abdominoperineal resection 535 (43) 397 (43) 138 (42)   175 (42) 360 (43)  
Pelvic Exenteration 32 (3) 14 (2) 18 (6)   9 (2) 23 (3)  
Unknown 13 (1) 11 (1) 2 (1)   3 (1) 10 (1)  
Total mesorectal excision, n (%) Yes 1066 (86) 783 (86) 283 (87) NS 372 (89) 694 (84) NS
No 20 (2) 12 (1) 8 (2)   7 (2) 13 (2)  
Unknown 151 (12) 117 (13) 34 (11)   39 (9) 112 (14)  
Circumferential resection margin, n (%) >  1 mm (uninvolved) 1061 (86) 782 (86) 279 (86) NS 358 (86) 703 (85) 0.03
1 mm (involved) 103 (8) 72 (8) 31 (10)   27 (6) 76 (9)  
Unknown 73 (6) 58 (6) 15 (5)   33 (8) 40 (5)  
  1. nCRT Neoadjuvant chemoradiotherapy, NLR Neutrophil-to-lymphocyte ratio, NS Non-significant, PLR Platelet-to-lymphocyte ratio, TME Total Mesorectal Excision