Table 2 Treatment details
Variable | Total (N = 1237) | NLR | p-val | PLR | p-val | |||
|---|---|---|---|---|---|---|---|---|
<  4 (n = 912, 74%) | ≥ 4 (n = 325, 26%) | <  150 (n = 418, 34%) | ≥ 150 (n = 819, 66%) | |||||
Neoadjuvant chemotherapy, n (%) | 5-fluorouracil | 764 (62) | 558 (61) | 206 (63) | NS | 256 (61) | 508 (62) | NS |
Capecitabine | 430 (35) | 322 (35) | 108 (33) | 149 (36) | 281 (34) | |||
Raltitrexed | 15 (1) | 14 (1) | 1 (0) | 5 (1) | 10 (1) | |||
Unknown | 28 (2) | 18 (2) | 10 (3) | 8 (2) | 20 (3) | |||
Radiotherapy dose (Gy), n (%) | Median (range) | 50 (20–80) | 50 (20–74) | 50 (29–80) | NS | 50 (20–74) | 60 (22–80) | NS |
<  44 | 36 (3) | 32 (3) | 4 (1) | 0.02 | 15 (4) | 21 (3) | NS | |
44–46 | 225 (18) | 156 (17) | 69 (21) | 65 (15) | 160 (19) | |||
≥ 46 | 966 (78) | 719 (79) | 247 (76) | 333 (80) | 633 (77) | |||
Unknown | 10 (1) | 5 (1) | 5 (2) | 5 (1) | 5 (1) | |||
Time from nCRT completion to TME | <  6 weeks | 190 (15) | 139 (15) | 51 (16) | NS | 62 (15) | 128 (16) | NS |
6–12 weeks | 988 (80) | 725 (80) | 263 (81) | 335 (80) | 653 (80) | |||
>  12 weeks | 57 (5) | 46 (5) | 11 (3) | 20 (5) | 37 (4) | |||
Unknown | 2 (0) | 2 (0) | 0 (0) | 1 (0) | 1 (0) | |||
Adjuvant chemotherapy, n (%) | 5-fluorouracil | 214 (17) | 159 (17) | 55 (17) | NS | 78 (19) | 136 (17) | NS |
Capecitabine | 336 (27) | 249 (27) | 87 (27) | 99 (24) | 237 (29) | |||
5-fluorouracil / oxaliplatin | 275 (22) | 199 (22) | 76 (23) | 96 (23) | 179 (22) | |||
Capecitabine / oxaliplatin | 64 (5) | 50 (5) | 14 (4) | 32 (8) | 32 (4) | |||
Other | 10 (1) | 8 (1) | 2 (1) | 4 (0) | 6 (1) | |||
No adjuvant chemotherapy | 338 (27) | 247 (27) | 91 (28) | 109 (26) | 229 (28) | |||
Completed treatment as planned, n (%) | Neoadjuvant radiotherapy | 1171 (95) | 859 (94) | 312 (96) | NS | 394 (94) | 777 (95) | NS |
Neoadjuvant chemotherapy | 1001 (81) | 734 (80) | 267 (82) | NS | 333 (80) | 668 (82) | NS | |
Type of surgery, n (%) | Low anterior resection | 657 (53) | 490 (54) | 167 (51) | NS | 231 (55) | 426 (52) | NS |
Abdominoperineal resection | 535 (43) | 397 (43) | 138 (42) | 175 (42) | 360 (43) | |||
Pelvic Exenteration | 32 (3) | 14 (2) | 18 (6) | 9 (2) | 23 (3) | |||
Unknown | 13 (1) | 11 (1) | 2 (1) | 3 (1) | 10 (1) | |||
Total mesorectal excision, n (%) | Yes | 1066 (86) | 783 (86) | 283 (87) | NS | 372 (89) | 694 (84) | NS |
No | 20 (2) | 12 (1) | 8 (2) | 7 (2) | 13 (2) | |||
Unknown | 151 (12) | 117 (13) | 34 (11) | 39 (9) | 112 (14) | |||
Circumferential resection margin, n (%) | >  1 mm (uninvolved) | 1061 (86) | 782 (86) | 279 (86) | NS | 358 (86) | 703 (85) | 0.03 |
⩽ 1 mm (involved) | 103 (8) | 72 (8) | 31 (10) | 27 (6) | 76 (9) | |||
Unknown | 73 (6) | 58 (6) | 15 (5) | 33 (8) | 40 (5) | |||