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Table 1 Baseline Patient and Tumour Characteristics

From: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictive and prognostic markers in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiation

Variable

 

Total (n = 1237)

NLR

p-val

PLR

p-val

<  4 (n = 912, 74%)

≥ 4 (n = 325, 26%)

<  150 (n = 418, 34%)

≥ 150 (n = 819, 66%)

Province, n (%)

Alberta

595 (48)

435 (48)

160 (49)

NS

226 (54)

369 (45)

< 0.01

British Columbia

255 (21)

186 (20)

69 (21)

 

69 (17)

186 (23)

 

Ontario

387 (31)

291 (32)

96 (30)

 

123 (29)

264 (32)

 

Age, years

Median (range)

62 (23–88)

61 (23–88)

64 (24–87)

< 0.01

62 (23–85)

62 (23–88)

NS

≥65, n (%)

482 (39)

334 (37)

148 (46)

< 0.01

154 (37)

328 (40)

NS

Male, n (%)

 

858 (69)

632 (69)

226 (70)

NS

302 (72)

556 (68)

NS

BMI, kg/m2 | n = 1130

≥ 25, n (%)

729 (59)

553 (61)

176 (54)

NS

272 (65)

457 (56)

< 0.01

ECOG PS, n (%)

0

524 (42)

398 (44)

126 (39)

< 0.01

188 (45)

336 (41)

NS

1

466 (38)

344 (38)

122 (38)

 

160 (38)

306 (37)

 

2+

62 (5)

32 (4)

30 (9)

 

13 (3)

49 (6)

 

Unknown

185 (15)

138 (15)

47 (14)

 

57 (14)

128 (16)

 

Distance from anal verge, n (%) | n = 1166

Median (range)

6 (0–30)

6 (0–30)

6 (0–25)

NS

6 (0–20)

6 (0–30)

NS

<  5 cm

415 (34)

306 (33)

109 (34)

NS

137 (33)

278 (34)

NS

5–10 cm

507 (41)

381 (42)

126 (39)

 

178 (43)

329 (40)

 

>  10 cm

244 (20)

181 (20)

63 (19)

 

84 (20)

160 (20)

 

Unknown

71 (6)

44 (5)

27 (8)

 

19 (4)

52 (6)

 

Pre-treatment CEA, n (%) | n = 1093

Median (range)

4 (0–1133)

3 (0–857)

4 (0–1133)

NS

3 (0–468)

4 (0–1133)

NS

<  5 ng/mL

667 (54)

510 (56)

157 (48)

NS

230 (55)

437 (53)

NS

≥ 5 ng/mL

426 (34)

301 (33)

125 (39)

 

142 (34)

284 (35)

 

Unknown

144 (12)

101 (11)

43 (13)

 

46 (11)

98 (12)

 

Clinical stage, n (%)

II

341 (28)

253 (28)

88 (27)

NS

119 (28)

222 (27)

NS

III

880 (71)

644 (71)

236 (73)

 

291 (70)

589 (72)

 

Unknown

16 (1)

15 (2)

1 (0)

 

8 (2)

8 (1)

 

Hemoglobin (g/dl)

Median (range)

136 (68–183)

137 (68–183)

131 (68–178)

< 0.01

140 (93–183)

133 (68–178)

< 0.01

  1. BMI Body Mass Index, ECOG PS Eastern Cooperative Oncology Group Performance Status, CEA Carcinoembryonic Antigen, NLR Neutrophil-to-lymphocyte ratio, NS Non-significant, PLR Platelet-to-lymphocyte ratio
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BMC Cancer

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