Fig. 7

Effects of cisplatin (CDDP), 6 mg/kg of body weight, alone or with caffeine (caf) or citrate (CA) at 100 mg/kg or caffeine citrate (cafCA) at 200 mg/kg (R1-chemotherapy) to treat mice implanted mouse osteosarcoma and human fibrosarcoma. a Tumor sizes were measured 2 times a week and the volumes calculated, and mean weights of tumors removed at necropsy. Two panels show an excisional tumor on day 15. From left to right, the tumor treated with saline (control), cisplatin alone, cisplatin with caffeine, cisplatin with citrate, and cisplatin with caffeine citrate. Scale bar = 2.5 cm. b Changes in body weight of mice without tumors after 3 courses of chemotherapy (cisplatin [CDDP], 6 mg/kg of body weight, alone or with caffeine [caf] or citrate [CA] at 100 mg/kg or caffeine citrate [cafCA] at 200 mg/kg) to test for adverse effects