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Fig. 2 | BMC Cancer

Fig. 2

From: Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo

Fig. 2

(a) Effect of caffeine citrate-potentiated chemotherapy on the survival of human (HOS) and mouse (LM8) osteosarcoma cells and human fibrosarcoma cells (HT1080). The cells were treated for 72 h with physiologic saline as a control or with the indicated concentration of cisplatin (CDDP) alone or combined with caffeine, citrate, or caffeine citrate. Relative numbers of viable cells were measured by the WST-8 assay. Values shown are the means ± standard deviation of four separate experiments. (b) The combination index values for cisplatin (CDDP) + caffeine citrate were significantly < 1, indicating a synergistic effect at all CDDP doses in treating human (HOS) and mouse (LM8) osteosarcoma cells and human fibrosarcoma cells (HT1080)

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