Fig. 8
From: The role of clonal communication and heterogeneity in breast cancer
Clone communication by released soluble factors. a-d Metabolic activity by MTT assay of clonal cell lines, 72 h after medium complementation with supernatant extracted from MDA-MB-231, GFP C3, mKO E10 and Sapphire D7 cell line. Each graph corresponds to a cell line donor medium, (a) MDA-MB-231, (b) GFP C3, (c) mKO E10 and (d) Sapphire D7. Color bars indicate the receiving cell line. e Metabolic activity measurement of MDA-MB-231 by MTT assay after complementation with non-complemented medium (C-), 50% complemented medium (CM) and exosomes. Significant differences were determined using unpaired t-test with Welch’s correction. Asterisks indicate significant differences when P-values are < 0.05 (*), < 0.01 (**), and < 0.001 (***)