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Table 4 Cox proportional hazards models for DSS

From: Development of nomograms for prognostication of patients with primary soft tissue sarcomas of the trunk and extremity: report from the Bone and Soft Tissue Tumor Registry in Japan

 

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Age

  < 30

Reference

 

Reference

 

 30–49

0.72 (0.34–1.51)

0.383

0.69 (0.32–1.46)

0.332

 50–69

1.23 (0.64–2.37)

0.541

0.93 (0.46–1.87)

0.844

 70-

2.21 (1.16–4.21)

0.016

1.72 (0.86–3.43)

0.127

Sex

 Male

Reference

 

Reference

 

 Female

0.79 (0.60–1.03)

0.076

0.90 (0.68–1.17)

0.426

Site

 Lower extremity

Reference

 

Reference

 

 Upper extremity

1.10 (0.77–1.56)

0.616

1.21 (0.84–1.74)

0.300

 Trunk

1.54 (1.12–2.11)

0.007

1.41 (1.01–1.95)

0.041

Depth

 Superficial

Reference

 

Reference

 

 Deep

2.48 (1.70–3.62)

< 0.001

1.58 (1.06–2.38)

0.026

Size

 5 cm<

Reference

 

Reference

 

 5 cm≤, < 10 cm

2.41 (1.57–3.68)

< 0.001

2.19 (1.41–3.39)

< 0.001

 10 cm≤

5.20 (3.44–7.85)

< 0.001

4.73 (3.03–7.38)

< 0.001

Histological diagnosis

 MLS

Reference

 

Reference

 

 LMS

4.66 (2.31–9.39)

< 0.001

2.94 (1.41–6.10)

0.004

 DDLS

2.66 (1.2–5.85)

0.015

0.92 (0.41–2.10)

0.851

 MFS

4.62 (2.1–10.18)

< 0.001

3.21 (1.43–7.20)

0.005

 MPNST

1.91 (0.89–4.1)

0.098

1.37 (0.62–3.03)

0.433

 SySa

1.03 (0.35–3.01)

0.959

0.88 (0.29–2.62)

0.811

 UPS

3.48 (1.8–6.73)

< 0.001

1.90 (0.95–3.78)

0.070

 Angiosarcoma

13.51 (4.91–37.19)

< 0.001

11.40 (4.05–32.10)

< 0.001

 PLS

1.80 (0.56–5.74)

0.320

0.87 (0.27–2.80)

0.812

 Others

3.34 (1.68–6.65)

< 0.001

2.89 (1.42–5.89)

0.003

Histological grade

 Low

Reference

 

Reference

 

 High

6.88 (3.40–13.92)

< 0.001

5.37 (2.61–11.04)

< 0.001

Nodal metastasis

 Negative

Reference

 

Reference

 

 Positive

2.95 (1.56–5.55)

< 0.001

1.95 (1.00–3.80)

0.051

Surgical margin

 Negative

Reference

 

Reference

 

 Positive

2.15 (1.42–3.25)

< 0.001

1.54 (1.01–2.36)

0.048

  1. CI confidence interval, MLS myxoid liposarcoma, LMS leiomyosarcoma, DDLS dedifferentiated liposarcoma, MPNST malignant peripheral nerve sheath tumor, MFS myxofibrosarcoma, SySa synovial sarcoma, UPS undifferentiated pleomorphic sarcoma, PLS pleomorphic liposarcoma