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Table 4 Cox proportional hazards models for DSS

From: Development of nomograms for prognostication of patients with primary soft tissue sarcomas of the trunk and extremity: report from the Bone and Soft Tissue Tumor Registry in Japan

  Univariate analysis Multivariate analysis
Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
Age
  < 30 Reference   Reference  
 30–49 0.72 (0.34–1.51) 0.383 0.69 (0.32–1.46) 0.332
 50–69 1.23 (0.64–2.37) 0.541 0.93 (0.46–1.87) 0.844
 70- 2.21 (1.16–4.21) 0.016 1.72 (0.86–3.43) 0.127
Sex
 Male Reference   Reference  
 Female 0.79 (0.60–1.03) 0.076 0.90 (0.68–1.17) 0.426
Site
 Lower extremity Reference   Reference  
 Upper extremity 1.10 (0.77–1.56) 0.616 1.21 (0.84–1.74) 0.300
 Trunk 1.54 (1.12–2.11) 0.007 1.41 (1.01–1.95) 0.041
Depth
 Superficial Reference   Reference  
 Deep 2.48 (1.70–3.62) < 0.001 1.58 (1.06–2.38) 0.026
Size
 5 cm< Reference   Reference  
 5 cm≤, < 10 cm 2.41 (1.57–3.68) < 0.001 2.19 (1.41–3.39) < 0.001
 10 cm≤ 5.20 (3.44–7.85) < 0.001 4.73 (3.03–7.38) < 0.001
Histological diagnosis
 MLS Reference   Reference  
 LMS 4.66 (2.31–9.39) < 0.001 2.94 (1.41–6.10) 0.004
 DDLS 2.66 (1.2–5.85) 0.015 0.92 (0.41–2.10) 0.851
 MFS 4.62 (2.1–10.18) < 0.001 3.21 (1.43–7.20) 0.005
 MPNST 1.91 (0.89–4.1) 0.098 1.37 (0.62–3.03) 0.433
 SySa 1.03 (0.35–3.01) 0.959 0.88 (0.29–2.62) 0.811
 UPS 3.48 (1.8–6.73) < 0.001 1.90 (0.95–3.78) 0.070
 Angiosarcoma 13.51 (4.91–37.19) < 0.001 11.40 (4.05–32.10) < 0.001
 PLS 1.80 (0.56–5.74) 0.320 0.87 (0.27–2.80) 0.812
 Others 3.34 (1.68–6.65) < 0.001 2.89 (1.42–5.89) 0.003
Histological grade
 Low Reference   Reference  
 High 6.88 (3.40–13.92) < 0.001 5.37 (2.61–11.04) < 0.001
Nodal metastasis
 Negative Reference   Reference  
 Positive 2.95 (1.56–5.55) < 0.001 1.95 (1.00–3.80) 0.051
Surgical margin
 Negative Reference   Reference  
 Positive 2.15 (1.42–3.25) < 0.001 1.54 (1.01–2.36) 0.048
  1. CI confidence interval, MLS myxoid liposarcoma, LMS leiomyosarcoma, DDLS dedifferentiated liposarcoma, MPNST malignant peripheral nerve sheath tumor, MFS myxofibrosarcoma, SySa synovial sarcoma, UPS undifferentiated pleomorphic sarcoma, PLS pleomorphic liposarcoma