Table 3 Cox proportional hazards models for DMFS
Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
Age | ||||
< 30 | Reference | Reference | ||
30–49 | 0.68 (0.45–1.03) | 0.069 | 0.67 (0.43–1.02) | 0.062 |
50–69 | 1.16 (0.80–1.68) | 0.435 | 0.94 (0.63–1.41) | 0.777 |
70- | 1.27 (0.88–1.84) | 0.202 | 1.02 (0.68–1.54) | 0.909 |
Sex | ||||
Male | Reference | Reference | ||
Female | 0.79 (0.67–0.94) | 0.007 | 0.89 (0.74–1.05) | 0.166 |
Site | ||||
Lower extremity | Reference | Reference | ||
Upper extremity | 0.97 (0.77–1.22) | 0.773 | 1.07 (0.85–1.35) | 0.576 |
Trunk | 1.12 (0.90–1.39) | 0.314 | 1.05 (0.83–1.31) | 0.696 |
Depth | ||||
Superficial | Reference | Reference | ||
Deep | 1.92 (1.54–2.39) | < 0.001 | 1.34 (1.06–1.70) | 0.015 |
Size | ||||
5 cm< | Reference | Reference | ||
5 cm≤, < 10 cm | 2.13 (1.67–2.72) | < 0.001 | 2.02 (1.57–2.60) | < 0.001 |
10 cm≤ | 3.46 (2.71–4.42) | < 0.001 | 3.39 (2.59–4.43) | < 0.001 |
Histological diagnosis | ||||
MLS | Reference | Reference | ||
LMS | 3.79 (2.59–5.54) | < 0.001 | 2.98 (2.00–4.45) | < 0.001 |
DDLS | 1.40 (0.87–2.26) | 0.166 | 0.70 (0.42–1.15) | 0.160 |
MFS | 2.31 (1.42–3.76) | < 0.001 | 1.87 (1.14–3.08) | 0.014 |
MPNST | 1.29 (0.84–1.99) | 0.245 | 1.19 (0.76–1.86) | 0.454 |
SySa | 1.52 (0.92–2.49) | 0.099 | 1.35 (0.81–2.27) | 0.250 |
UPS | 2.33 (1.63–3.32) | < 0.001 | 1.64 (1.12–2.38) | 0.011 |
Angiosarcoma | 4.04 (1.80–9.07) | < 0.001 | 4.04 (1.78–9.15) | < 0.001 |
PLS | 2.27 (1.29–3.99) | 0.004 | 1.38 (0.78–2.45) | 0.274 |
Others | 1.81 (1.23–2.67) | 0.003 | 1.91 (1.28–2.86) | 0.002 |
Histological grade | ||||
Low | Reference | Reference | ||
High | 5.19 (3.52–7.64) | < 0.001 | 4.08 (2.74–6.09) | < 0.001 |
Nodal metastasis | ||||
Negative | Reference | Reference | ||
Positive | 2.69 (1.70–4.25) | < 0.001 | 2.06 (1.28–3.31) | 0.003 |
Surgical margin | ||||
Negative | Reference | Reference | ||
Positive | 1.35 (0.98–1.88) | 0.067 | 1.15 (0.83–1.6) | 0.404 |