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Table 3 Cox proportional hazards models for DMFS

From: Development of nomograms for prognostication of patients with primary soft tissue sarcomas of the trunk and extremity: report from the Bone and Soft Tissue Tumor Registry in Japan

  Univariate analysis Multivariate analysis
Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
Age
  < 30 Reference   Reference  
 30–49 0.68 (0.45–1.03) 0.069 0.67 (0.43–1.02) 0.062
 50–69 1.16 (0.80–1.68) 0.435 0.94 (0.63–1.41) 0.777
 70- 1.27 (0.88–1.84) 0.202 1.02 (0.68–1.54) 0.909
Sex
 Male Reference   Reference  
 Female 0.79 (0.67–0.94) 0.007 0.89 (0.74–1.05) 0.166
Site
 Lower extremity Reference   Reference  
 Upper extremity 0.97 (0.77–1.22) 0.773 1.07 (0.85–1.35) 0.576
 Trunk 1.12 (0.90–1.39) 0.314 1.05 (0.83–1.31) 0.696
Depth
 Superficial Reference   Reference  
 Deep 1.92 (1.54–2.39) < 0.001 1.34 (1.06–1.70) 0.015
Size
 5 cm< Reference   Reference  
 5 cm≤, < 10 cm 2.13 (1.67–2.72) < 0.001 2.02 (1.57–2.60) < 0.001
 10 cm≤ 3.46 (2.71–4.42) < 0.001 3.39 (2.59–4.43) < 0.001
Histological diagnosis
 MLS Reference   Reference  
 LMS 3.79 (2.59–5.54) < 0.001 2.98 (2.00–4.45) < 0.001
 DDLS 1.40 (0.87–2.26) 0.166 0.70 (0.42–1.15) 0.160
 MFS 2.31 (1.42–3.76) < 0.001 1.87 (1.14–3.08) 0.014
 MPNST 1.29 (0.84–1.99) 0.245 1.19 (0.76–1.86) 0.454
 SySa 1.52 (0.92–2.49) 0.099 1.35 (0.81–2.27) 0.250
 UPS 2.33 (1.63–3.32) < 0.001 1.64 (1.12–2.38) 0.011
 Angiosarcoma 4.04 (1.80–9.07) < 0.001 4.04 (1.78–9.15) < 0.001
 PLS 2.27 (1.29–3.99) 0.004 1.38 (0.78–2.45) 0.274
 Others 1.81 (1.23–2.67) 0.003 1.91 (1.28–2.86) 0.002
Histological grade
 Low Reference   Reference  
 High 5.19 (3.52–7.64) < 0.001 4.08 (2.74–6.09) < 0.001
Nodal metastasis
 Negative Reference   Reference  
 Positive 2.69 (1.70–4.25) < 0.001 2.06 (1.28–3.31) 0.003
Surgical margin
 Negative Reference   Reference  
 Positive 1.35 (0.98–1.88) 0.067 1.15 (0.83–1.6) 0.404
  1. CI confidence interval, MLS myxoid liposarcoma, LMS leiomyosarcoma, DDLS dedifferentiated liposarcoma, MPNST malignant peripheral nerve sheath tumor, MFS myxofibrosarcoma, SySa synovial sarcoma, UPS undifferentiated pleomorphic sarcoma, PLS pleomorphic liposarcoma