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Table 3 Cox regression analysis for predictors of overall survival in patients with CRC in our cohort

From: Eukaryotic elongation factor-2 kinase expression is an independent prognostic factor in colorectal cancer

Variable Univariate Multivariate
HR 95% CI p value HR 95% CI p value
Gender (Female vs Male) 1.11 0.69–1.82 0.673 0.87 0.67–1.13 0.289
Age (≥65 vs < 65) 1.01 0.61–1.67 0.963 1.16 0.67–2.00 0.606
Tumor location (colon vs rectum) 1.09 0.64–1.84 0.751    
Tumor grade (poor vs moderate to well) 18.8 6.99–50.7 < 0.001* 3.27 0.98–10.9 0.053
Tumor stage (T4 vs T1 to T3) 4.78 2.77–8.27 < 0.001* 3.81 1.92–7.56 < 0.001*
Lymph node invasion (Presence vs Absence) 3.11 1.87–5.17 < 0.001* 2.54 1.47–4.37 0.001*
Metastasis (Presence vs Absence) 9.95 5.25–18.9 < 0.001* 4.04 1.70–9.61 0.002*
MSI (MS unstable vs MS stable) 0.53 0.22–1.23 0.138    
EEF2K expression (Negative vs Positive) 2.81 1.21–6.51 0.016* 2.95 1.24–7.02 0.014*
  1. HR hazard ratio, CI confidence interval, MS microsatellite, MSI microsatellite instability, * p < 0.05