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Table 3 Cox regression analysis for predictors of overall survival in patients with CRC in our cohort

From: Eukaryotic elongation factor-2 kinase expression is an independent prognostic factor in colorectal cancer

Variable

Univariate

Multivariate

HR

95% CI

p value

HR

95% CI

p value

Gender (Female vs Male)

1.11

0.69–1.82

0.673

0.87

0.67–1.13

0.289

Age (≥65 vs < 65)

1.01

0.61–1.67

0.963

1.16

0.67–2.00

0.606

Tumor location (colon vs rectum)

1.09

0.64–1.84

0.751

   

Tumor grade (poor vs moderate to well)

18.8

6.99–50.7

< 0.001*

3.27

0.98–10.9

0.053

Tumor stage (T4 vs T1 to T3)

4.78

2.77–8.27

< 0.001*

3.81

1.92–7.56

< 0.001*

Lymph node invasion (Presence vs Absence)

3.11

1.87–5.17

< 0.001*

2.54

1.47–4.37

0.001*

Metastasis (Presence vs Absence)

9.95

5.25–18.9

< 0.001*

4.04

1.70–9.61

0.002*

MSI (MS unstable vs MS stable)

0.53

0.22–1.23

0.138

   

EEF2K expression (Negative vs Positive)

2.81

1.21–6.51

0.016*

2.95

1.24–7.02

0.014*

  1. HR hazard ratio, CI confidence interval, MS microsatellite, MSI microsatellite instability, * p < 0.05