Hypofractionated radiotherapy as a salvage treatment for recurrent hepatocellular carcinoma with inferior vena cava/right atrium tumor thrombus: a multi-center analysis

Table 2 Log-rank test for characteristics of survival in 75 patients

Variables	n	OS (mo)	log-rank test P values
Gender
Female	9	12.2 ± 1.79	0.753
Male	66	13.4 ± 1.15
Age
< 50	27	12.5 ± 1.43	0.613
≥ 50	48	13.6 ± 1.38
Child-Pugh classification
A	66	13.9 ± 1.09	< 0.001
B	9	6.4 ± 0.80
Performance status
0	17	14.3 ± 2.39	0.728
1	58	12.9 ± 1.11
HBsAg
Negative	6	15.5 ± 2.41	0.462
Positive	69	12.9 ± 1.09
AFP (μg/L)
< 400	44	14.8 ± 1.59	0.041
≥ 400	31	10.9 ± 0.92
No. of prior therapies
< 4	35	12.8 ± 1.43	0.648
≥ 4	40	13.6 ± 1.44
Intrahepatic tumor number
Solitary	54	15.1 ± 1.25	< 0.001
Multiple	21	7.6 ± 0.59
LN metastases
Absent	66	13.6 ± 1.11	0.223
Present	9	10.6 ± 2.51
Distant metastases
Absent	55	14.7 ± 1.29	0.001
Present	20	8.8 ± 0.58
PTV
TT	29	7.6 ± 0.61	< 0.001
TT + PT	46	16.3 ± 1.34
BED Dose (Gy)
< 55	43	10.5 ± 0.97	0.001
≥ 55	32	16.6 ± 1.76
Further radiotherapy
Yes	37	17.3 ± 1.58	< 0.001
No	38	8.6 ± 0.59
Thrombus location
IVC only	57	13.8 ± 1.13	0.205
IVC + RA	18	11.6 ± 2.48

Abbreviations: OS overall survival, AFP α-fetoprotein, LN lymphonodus, TT tumor thrombus, PTV planning target volume, PT primary tumors, BED biological effective dose, IVC inferior vena cava, RA right atrium