Fig. 7
From: APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression
Molecular characterization (FOXL2, Inhibin-α, Ki67, CD34, cleaved caspase-3) of GCTs developing in aged (12–18 month) Apc2 deficient ovaries. Representative photomicrographs of immunohistochemical staining of GCTs developing in Apc2+/+ ovaries (left column) and in Apc2+/− (middle column) and Apc2−/− (right column) for FOXL2 protein, Inhibin-α, Ki67, CD34 and cleaved caspase-3 (showing absence of apoptosis in GCT). Note all genotypes also carried an Apc hypomorphic allele. Bar = 500 μm for main panel, 50 μm for insets. To maintain resolution, insets have been cropped from a representative area of a separate high power photograph, rather than a magnification of the main panel figure