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Fig. 5 | BMC Cancer

Fig. 5

From: APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression

Fig. 5

APC2 loss impairs follicle steroidogenesis and vascularization. a Representative photomicrographs of CD34 immunostaining of follicles in Apc2+/+ and Apc2−/− 10-week-old ovaries. Bars = 100 μm; insets are magnified 2X. b, c Gene expression levels of (b) Vegfa, and (c) steroidogenic enzymes by qRT-PCR on ovaries of 10-week-old Apc2+/+ and Apc2−/− female mice (mean ± 95% confidence intervals; n = 4 for all measurements except for Cyp19a1 in Apc2−/− where n = 3; *P < 0.05, **P < 0.01, determined from confidence intervals) [45]

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