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Fig. 3 | BMC Cancer

Fig. 3

From: APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression

Fig. 3

APC2-deficiency impairs follicular growth in the ovary. a Histogram showing total number of primary (1ry), secondary (2ry), antral and pre-ovulatory follicles in Apc2+/+ and Apc2−/− ovarian sections (mean ± SE; n = 4; no significant differences, t-test). b Size distribution of healthy antral and pre-ovulatory follicles (mean ± SE; n = 4; *P < 0.05, t-test). c Histogram showing a > 2-fold increase of apoptosis in granulosa cells of Apc2−/− follicles (mean ± SE; n = 4; *P < 0.05, t-test). d, e Representative photomicrographs of cleaved caspase 3 immunostaining in (d) Apc2−/− and (e) Apc2+/+ granulosa cells. Bars = 100 μm

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