BRAF kinase activity | BRAF a | RAS or PIK3CAa |
---|---|---|
Coexisting BRAF and RASb | ||
 Class-2 BRAF mutation | p.K601E (35%) | NRAS p.G13 N (34%) |
p.G464R (5.5%) | NRAS p.Q61R (55%) | |
 Class-3 BRAF mutation | p.G466A (30%) | KRAS p.G12D (49%) |
p.G466 V (19%) | HRAS p.G13 N (26%) | |
p.S467 L (26%) | NRAS p.Q61K (24%) | |
p.D594N (47%) | NRAS p.G12S (42%) | |
p.D594N (59%) | HRAS p.Q61K (46%) | |
Coexisting BRAF and PIK3CAc | ||
 Class-1 BRAF mutation | p.V600E (11%) | PIK3CA p.545 K (7.5%) |
p.V600K (56%) | PIK3CA p.545 K (24%) | |
 Class-3 BRAF mutation | p.G466E (17%) | PIK3CA p.545 K (3.1%) |