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Table 3 Incidences of class-1, class-2 and class-3 BRAF mutations

From: Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing

  BRAF Class-1 p.V600E p.V600K Class-2 Class-3 Unclassified
Uveal (n = 2) 0 0 0 0 0 0 0
Mucosal (n = 20) 1 0 0 0 0 1 0
Cutaneous (n = 286) 132 (46%) 105 (37%)a 82 (29%) 20 (7.0%) 10 (3.5%) 14 (4.9%) 3
H/N/UB (n = 98) 44 (45%) 28 (29%) 14 (14%) 14 (14%) 5 (5.1%) 10 (10%) 1
non-H/N/UB (n = 188) 88 (47%) 77 (41%)a 68 (36%) 6 (3.2%) 5 (2.7%) 4 (2.1%) 2
Others (n = 138)b 56 (41%) 42 (30%) 35 (25%) 7 (5.1%) 4 (2.9%) 7 (5.1%) 4
Total (n = 446) 189 (42%) 147 (33%) a 117 (26%) 27 (6.1%) 14 (3.1%) 22 (4.9%) 7 (1.6%)
  1. H/N/UB: Primary tumors at head, neck or upper back
  2. aIncluding 3 tumors with p.V600R
  3. bMetastatic melanomas of unknown origin or without information of the primary site, including one tumor with p.S605I and p.V600E within the same allele