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Table 3 Incidences of class-1, class-2 and class-3 BRAF mutations

From: Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing

 

BRAF

Class-1

p.V600E

p.V600K

Class-2

Class-3

Unclassified

Uveal (n = 2)

0

0

0

0

0

0

0

Mucosal (n = 20)

1

0

0

0

0

1

0

Cutaneous (n = 286)

132 (46%)

105 (37%)a

82 (29%)

20 (7.0%)

10 (3.5%)

14 (4.9%)

3

H/N/UB (n = 98)

44 (45%)

28 (29%)

14 (14%)

14 (14%)

5 (5.1%)

10 (10%)

1

non-H/N/UB (n = 188)

88 (47%)

77 (41%)a

68 (36%)

6 (3.2%)

5 (2.7%)

4 (2.1%)

2

Others (n = 138)b

56 (41%)

42 (30%)

35 (25%)

7 (5.1%)

4 (2.9%)

7 (5.1%)

4

Total (n = 446)

189 (42%)

147 (33%) a

117 (26%)

27 (6.1%)

14 (3.1%)

22 (4.9%)

7 (1.6%)

  1. H/N/UB: Primary tumors at head, neck or upper back
  2. aIncluding 3 tumors with p.V600R
  3. bMetastatic melanomas of unknown origin or without information of the primary site, including one tumor with p.S605I and p.V600E within the same allele