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Table 2 BRAF mutations in 189 melanomas

From: Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing

aa change cDNA change Exon Case No.a Classb
p.G464Ic c.1390_1391delinsAT 11 1 likely 2
p.G464R c.1390G > A 11 1 likely 2
p.G466A c.1397G > C 11 1 (1) 3
p.G466E c.1397G > A 11 2 3
p.G466 V c.1397G > T 11 3 (1) 3
p.S467 L c.1400C > T 11 4 (1) 3
p.G469A c.1406G > C 11 2 2
p.G469E c.1406G > A 11 2 (2) 3
p.G469R c.1405G > A 11 1 2
p.G469 V c.1406G > T 11 1 (1) 2
p.N581I c.1742A > T 15 1 3
p.N581 T c.1742A > C 15 1 likely 3
p.L584F c.1750C > T 15 1 (1) UK
p.E586K c.1756G > A 15 1 UK
p.G593D c.1778G > A 15 1 UK
p.D594E c.1782 T > A 15 1 (1) 3
p.D594G c.1781A > G 15 1 (1) 3
p.D594N c.1780G > A 15 5 (2) 3
p.G596C c.1786G > T 15 1 likely 3
p.L597Q c.1790 T > A 15 2 (1) 2
p.L597R c.1790 T > G 15 1 (1) likely 2
p.L597S c.1789_1790delinsTC 15 1 likely 2
p.T599dup c.1795_1797dup 15 1 UK
p.V600E c.1799 T > Ad 15 117 (44) 1
p.V600K c.1798_1799delinsAA 15 27 (7) 1
p.V600R c.1798_1799delinsAG 15 3 (1) 1
p.K601E c.1801A > G 15 4 (2) 2
p.R603* c.1807C > T 15 1 UK
p.S605Ic c.1814G > T 15 1 (1) UK
p.S607F c.1820C > T 15 1 UK
  1. aa change: amino acid change; Case no.: case number. UK: unknown class
  2. aNumber in the parenthesis indicates case number of BRAF mutations previously reported [17]
  3. bLikely 2 or 3: other mutations involving the same codon have been categorized as 2 or 3
  4. cNot reported in the COSMIC database
  5. dTwo with c.1799_1800delinsAA