aa change

cDNA change

Exon

Case No.^{a}

Class^{b}


p.G464I^{c}

c.1390_1391delinsAT

11

1

likely 2

p.G464R

c.1390G > A

11

1

likely 2

p.G466A

c.1397G > C

11

1 (1)

3

p.G466E

c.1397G > A

11

2

3

p.G466 V

c.1397G > T

11

3 (1)

3

p.S467 L

c.1400C > T

11

4 (1)

3

p.G469A

c.1406G > C

11

2

2

p.G469E

c.1406G > A

11

2 (2)

3

p.G469R

c.1405G > A

11

1

2

p.G469 V

c.1406G > T

11

1 (1)

2

p.N581I

c.1742A > T

15

1

3

p.N581 T

c.1742A > C

15

1

likely 3

p.L584F

c.1750C > T

15

1 (1)

UK

p.E586K

c.1756G > A

15

1

UK

p.G593D

c.1778G > A

15

1

UK

p.D594E

c.1782 T > A

15

1 (1)

3

p.D594G

c.1781A > G

15

1 (1)

3

p.D594N

c.1780G > A

15

5 (2)

3

p.G596C

c.1786G > T

15

1

likely 3

p.L597Q

c.1790 T > A

15

2 (1)

2

p.L597R

c.1790 T > G

15

1 (1)

likely 2

p.L597S

c.1789_1790delinsTC

15

1

likely 2

p.T599dup

c.1795_1797dup

15

1

UK

p.V600E

c.1799 T > A^{d}

15

117 (44)

1

p.V600K

c.1798_1799delinsAA

15

27 (7)

1

p.V600R

c.1798_1799delinsAG

15

3 (1)

1

p.K601E

c.1801A > G

15

4 (2)

2

p.R603*

c.1807C > T

15

1

UK

p.S605I^{c}

c.1814G > T

15

1 (1)

UK

p.S607F

c.1820C > T

15

1

UK

 aa change: amino acid change; Case no.: case number. UK: unknown class
 ^{a}Number in the parenthesis indicates case number of BRAF mutations previously reported [17]
 ^{b}Likely 2 or 3: other mutations involving the same codon have been categorized as 2 or 3
 ^{c}Not reported in the COSMIC database
 ^{d}Two with c.1799_1800delinsAA