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Table 1 Mutational profiling of 446 melanomas

From: Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing

Melanoma Negative BRAF HRAS KRAS NRAS KIT PIK3CA
Uveal (n = 2) 2 (100%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%)
Mucosal (n = 20) 12 (60%) 1 (5.0%) 0 (0%) 1 (5.0%) 4 (20%) 3 (15%) 1 (5.0%)
Cutaneous (n = 286)a 72 (25%) 132 (46%) 9 (3.1%) 7 (2.4%) 64 (22%) 14 (4.9%) 6 (2.1%)
Others (n = 138)b 32 (23%) 56 (41%) 0 (0%) 4 (2.9%) 42 (30%) 5 (3.6%) 5 (3.6%)
Total (n = 446)a 118 (26%) 189 (42%) 9 (2.0%) 12 (2.7%) 110 (25%) 22 (4.9%) 12 (2.7%)
  1. a11 specimens with no mutation detected and an estimated tumor cellularity of less than 10% were excluded
  2. bMetastatic melanomas of unknown origin or without information of the primary site