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Table 5 Comparison of the pharmacokinetics of irinotecan and SN-38

From: Selective TACE with irinotecan-loaded 40 μm microspheres and FOLFIRI for colorectal liver metastases: phase I dose escalation pharmacokinetic study

  TANDEM-IRI FOLFIRI P value
AUC of irinotecan (hr*ng/ml) 4327.1 ± 2919.1 8958.1 ± 4484.1 N.S.
AUC/Dose of irinotecan 37.8 ± 12.8 36.9 ± 17.0 N.S
AUC of SN-38 (hr*ng/ml) 269.9 ± 148.3 165.7 ± 90.3 N.S
AUC/Dose of SN-38 3.01 ± 1.87 0.68 ± 0.36 0.009
Cmax of irinotecan (hr*ng/ml) 624.7 ± 469.7 1626.0 ± 264.1 <  0.001
Cmax/Dose of irinotecan 5.4 ± 2.4 6.8 ± 1.2 N.S
Cmax of SN-38 (hr*ng/ml) 30.4 ± 17.1 18.8 ± 6.3 N.S
Cmax/Dose of SN-38 0.32 ± 0.11 0.08 ± 0.03 <  0.001
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