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Table 3 Doses and injection times of TANDEM-IRI and FOLFIRI

From: Selective TACE with irinotecan-loaded 40 μm microspheres and FOLFIRI for colorectal liver metastases: phase I dose escalation pharmacokinetic study

 

Level 1

Level 2

Level 3

Patient

1

2

3

4

5

6

7

8

9

Microsphere Dose (ml)

1.0

1.7

1.0

1.0

1.0

1.67

1.5

1.5

2.0

Irinotecan Dose (mg)

50

85

50

75

75

125

150

150

200

Injection Time (hr)

1.05

1.4

0.83

0.95

1.07

1.13

1.45

1.53

1.27

FOLFIRI Dose (mg)

228

246

262

265

214

232.5

234

226

255

Injection Time (hr)

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5