Table 1 Definition of dose-limiting toxicity

Definition of dose-limiting toxicity

• Grade 4 neutropenia or thrombocytopenia

• Grade 3 or 4 neutropenia plus fever higher than 38.0 °C

• Grade 4 aspartate transaminase and/or alanine transaminase elevation were held over 1 week

• Serum total bilirubin was ≧5 mg/dl or ≧3 mg/dl was held over 2 weeks

• Liver abscess, cholangitis and cholecystitis required drainage and surgical resection

• Non-hematologic toxicities of grade 3 or more (excluding that from disease progression, fatigue, fever, nausea, vomiting, pain and alopecia)