Fig. 3

A case received curative surgical resection. This patient had 5 liver metastases, 4 in the left lobe and 1 in the right lobe. There was no extrahepatic metastasis. a. CT before TACE shows multiple liver metastases (arrows). A tumor in segment 4 was close to the portal vein (arrowhead). b. Hepatic arteriography; the tumor feeding artery was detected (arrow) by the angiography and TACE navigation system. c. A catheter was selectively inserted into the tumor feeding artery and 40 μm irinotecan loaded TANDEM was injected. d. CT after 3 cycles of the treatment of TACE and FOLFIRI showed the tumor shrunk and was separated from the portal vein (arrow). A bile duct adjacent to the portal vein was slightly dilated. e. Histological findings (Hematoxylin and eosin stain) of the resected tumor; almost the whole area of the tumor was necrotic and numerous 40 μm microspheres were seen inside the tumor (arrows)